Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity

por Ghovanloo, Mohammad-Reza, Choudhury, Koushik, Bandaru, Tagore S., Fouda, Mohamed A., Rayani, Kaveh, Rusinova, Radda, Phaterpekar, Tejas, Nelkenbrecher, Karen, Watkins, Abeline R., Poburko, Damon, Thewalt, Jenifer, Andersen, Olaf S., Delemotte, Lucie, Goodchild, Samuel J., Ruben, Peter C.
Publicado 2021

NBI-921352, a first-in-class, Na(V)1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

por Johnson, JP, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R
Publicado 2022