Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link

por Chen, Chaobo, Nelson, Leonard J., Ávila, Matías A., Cubero, Francisco Javier
Publicado 2019

Dissecting the molecular pathophysiology of drug-induced liver injury

por Ye, Hui, Nelson, Leonard J, Gómez del Moral, Manuel, Martínez-Naves, Eduardo, Cubero, Francisco Javier
Publicado 2018

Profiling the Impact of Medium Formulation on Morphology and Functionality of Primary Hepatocytes in vitro

por Nelson, Leonard J., Treskes, Philipp, Howie, A. Forbes, Walker, Simon W., Hayes, Peter C., Plevris, John N.
Publicado 2013

Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death?

por Macías-Rodríguez, Ricardo U., Inzaugarat, María Eugenia, Ruiz-Margáin, Astrid, Nelson, Leonard J., Trautwein, Christian, Cubero, Francisco Javier
Publicado 2020

Fibrotic Events in the Progression of Cholestatic Liver Disease

por Wu, Hanghang, Chen, Chaobo, Ziani, Siham, Nelson, Leonard J., Ávila, Matías A., Nevzorova, Yulia A., Cubero, Francisco Javier
Publicado 2021

Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model

por Nelson, Leonard J., Navarro, Maria, Treskes, Philipp, Samuel, Kay, Tura-Ceide, Olga, Morley, Steven D., Hayes, Peter C., Plevris, John N.
Publicado 2015

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical...

por Nelson, Leonard J., Morgan, Katie, Treskes, Philipp, Samuel, Kay, Henderson, Catherine J., LeBled, Claire, Homer, Natalie, Grant, M. Helen, Hayes, Peter C., Plevris, John N.
Publicado 2016

Alcoholic liver disease: Utility of animal models

por Lamas-Paz, Arantza, Hao, Fengjie, Nelson, Leonard J, Vázquez, Maria Teresa, Canals, Santiago, Gómez del Moral, Manuel, Martínez-Naves, Eduardo, Nevzorova, Yulia A, Cubero, Francisco Javier
Publicado 2018

Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro

por Lockman, Khalida Ann, Htun, Varanand, Sinha, Rohit, Treskes, Philipp, Nelson, Leonard J., Martin, Sarah F., Rogers, Sophie M., Le Bihan, Thierry, Hayes, Peter C., Plevris, John N.
Publicado 2016

Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure

por Newsome, Philip N, Henderson, Neil C, Nelson, Leonard J, Dabos, Costas, Filippi, Celine, Bellamy, Chris, Howie, Forbes, Clutton, Richard E, King, Tim, Lee, Alistair, Hayes, Peter C, Plevris, John N
Publicado 2010

Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?

por Yeung, Emily N. W., Treskes, Philipp, Martin, Sarah F., Manning, Jonathan R., Dunbar, Donald R., Rogers, Sophie M., Le Bihan, Thierry, Lockman, K. Ann, Morley, Steven D., Hayes, Peter C., Nelson, Leonard J., Plevris, John N.
Publicado 2015

Erratum to: Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?

por Yeung, Emily N. W., Treskes, Philipp, Martin, Sarah F., Manning, Jonathan R., Dunbar, Donald R., Rogers, Sophie M., Le Bihan, Thierry, Lockman, K. Ann, Morley, Steven D., Hayes, Peter C., Nelson, Leonard J., Plevris, John N.
Publicado 2016

Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver

por Gamal, Wesam, Treskes, Philipp, Samuel, Kay, Sullivan, Gareth J., Siller, Richard, Srsen, Vlastimil, Morgan, Katie, Bryans, Anna, Kozlowska, Ada, Koulovasilopoulos, Andreas, Underwood, Ian, Smith, Stewart, del-Pozo, Jorge, Moss, Sharon, Thompson, Alexandra Inés, Henderson, Neil C., Hayes, Peter C., Plevris, John N., Bagnaninchi, Pierre-Olivier, Nelson, Leonard J.
Publicado 2017

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

por Sydor, Svenja, Manka, Paul, Best, Jan, Jafoui, Sami, Sowa, Jan-Peter, Zoubek, Miguel Eugenio, Hernandez-Gea, Virginia, Cubero, Francisco Javier, Kälsch, Julia, Vetter, Diana, Fiel, Maria Isabel, Hoshida, Yujin, Bian, C. Billie, Nelson, Leonard J., Moshage, Han, Faber, Klaas Nico, Paul, Andreas, Baba, Hideo A., Gerken, Guido, Friedman, Scott L., Canbay, Ali, Bechmann, Lars P.
Publicado 2017

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy

por Ye, Hui, Chen, Chaobo, Wu, Hanghang, Zheng, Kang, Martín-Adrados, Beatriz, Caparros, Esther, Francés, Rubén, Nelson, Leonard J., Gómez del Moral, Manuel, Asensio, Iris, Vaquero, Javier, Bañares, Rafael, Ávila, Matías A., Andrade, Raúl J., Isabel Lucena, M., Martínez-Chantar, Maria Luz, Reeves, Helen L., Masson, Steven, Blumberg, Richard S., Gracia-Sancho, Jordi, Nevzorova, Yulia A., Martínez-Naves, Eduardo, Cubero, Francisco Javier
Publicado 2022

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease

por Chen, Chaobo, Wu, Hanghang, Ye, Hui, Tortajada, Agustín, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Vidal, August, Peligros, Maria Isabel, Reissing, Johanna, Bruns, Tony, Mohamed, Mohamed Ramadan, Zheng, Kang, Lujambio, Amaia, Iraburu, Maria J., Colyn, Leticia, Latasa, Maria Ujue, Arechederra, María, Fernández-Barrena, Maite G., Berasain, Carmen, Vaquero, Javier, Bañares, Rafael, Nelson, Leonard J., Trautwein, Christian, Davis, Roger J., Martinez-Naves, Eduardo, Nevzorova, Yulia A., Villanueva, Alberto, Avila, Matias A., Cubero, Francisco Javier
Publicado 2021

Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures

por Arechederra, Maria, Rullán, María, Amat, Irene, Oyon, Daniel, Zabalza, Lucia, Elizalde, Maria, Latasa, M Ujue, Mercado, Maria R, Ruiz-Clavijo, David, Saldaña, Cristina, Fernández-Urién, Ignacio, Carrascosa, Juan, Jusué, Vanesa, Guerrero-Setas, David, Zazpe, Cruz, González-Borja, Iranzu, Sangro, Bruno, Herranz, Jose M, Purroy, Ana, Gil, Isabel, Nelson, Leonard J, Vila, Juan J, Krawczyk, Marcin, Zieniewicz, Krzysztof, Patkowski, Waldemar, Milkiewicz, Piotr, Cubero, Francisco Javier, Alkorta-Aranburu, Gorka, G Fernandez-Barrena, Maite, Urman, Jesus M, Berasain, Carmen, Avila, Matias A
Publicado 2022

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

por Colyn, Leticia, Alvarez-Sola, Gloria, Latasa, M. Ujue, Uriarte, Iker, Herranz, Jose M., Arechederra, Maria, Vlachogiannis, George, Rae, Colin, Pineda-Lucena, Antonio, Casadei-Gardini, Andrea, Pedica, Federica, Aldrighetti, Luca, López-López, Angeles, López-Gonzálvez, Angeles, Barbas, Coral, Ciordia, Sergio, Van Liempd, Sebastiaan M., Falcón-Pérez, Juan M., Urman, Jesus, Sangro, Bruno, Vicent, Silve, Iraburu, Maria J., Prosper, Felipe, Nelson, Leonard J., Banales, Jesus M., Martinez-Chantar, Maria Luz, Marin, Jose J. G., Braconi, Chiara, Trautwein, Christian, Corrales, Fernando J., Cubero, F. Javier, Berasain, Carmen, Fernandez-Barrena, Maite G., Avila, Matias A.
Publicado 2022