Future prospects for human genetics and genomics in drug discovery

por Ghoussaini, Maya, Nelson, Matthew R., Dunham, Ian
Publicado 2023

Comparison of Statistical Tests for Association between Rare Variants and Binary Traits

por Bacanu, Silviu-Alin, Nelson, Matthew R., Whittaker, John C.
Publicado 2012

Predicting clinically promising therapeutic hypotheses using tensor factorization

por Yao, Jin, Hurle, Mark R., Nelson, Matthew R., Agarwal, Pankaj
Publicado 2019

Improved genome inference in the MHC using a population reference graph

por Dilthey, Alexander, Cox, Charles, Iqbal, Zamin, Nelson, Matthew R., McVean, Gil
Publicado 2015

Copy number variation in African Americans

por McElroy, Joseph P, Nelson, Matthew R, Caillier, Stacy J, Oksenberg, Jorge R
Publicado 2009

Multi-Population Classical HLA Type Imputation

por Dilthey, Alexander, Leslie, Stephen, Moutsianas, Loukas, Shen, Judong, Cox, Charles, Nelson, Matthew R., McVean, Gil
Publicado 2013

Comparing variant calling algorithms for target-exon sequencing in a large sample

por Lo, Yancy, Kang, Hyun M, Nelson, Matthew R, Othman, Mohammad I, Chissoe, Stephanie L, Ehm, Margaret G, Abecasis, Gonçalo R, Zöllner, Sebastian
Publicado 2015

Association between a variation in the phosphodiesterase 4D gene and bone mineral density

por Reneland, Richard H, Mah, Steven, Kammerer, Stefan, Hoyal, Carolyn R, Marnellos, George, Wilson, Scott G, Sambrook, Philip N, Spector, Tim D, Nelson, Matthew R, Braun, Andreas
Publicado 2005

The influence of genomic context on mutation patterns in the human genome inferred from rare variants

por Schaibley, Valerie M., Zawistowski, Matthew, Wegmann, Daniel, Ehm, Margaret G., Nelson, Matthew R., St. Jean, Pamela L., Abecasis, Gonçalo R., Novembre, John, Zöllner, Sebastian, Li, Jun Z.
Publicado 2013

Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases

por Hoyal, Carolyn R, Kammerer, Stefan, Roth, Richard B, Reneland, Richard, Marnellos, George, Kiechle, Marion, Schwarz-Boeger, Ulrike, Griffiths, Lyn R, Ebner, Florian, Rehbock, Joachim, Nelson, Matthew R, Braun, Andreas
Publicado 2005

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies

por Li, Mulin Jun, Liu, Zipeng, Wang, Panwen, Wong, Maria P., Nelson, Matthew R., Kocher, Jean-Pierre A., Yeager, Meredith, Sham, Pak Chung, Chanock, Stephen J., Xia, Zhengyuan, Wang, Junwen
Publicado 2016

Performance of Genotype Imputation for Rare Variants Identified in Exons and Flanking Regions of Genes

por Li, Li, Li, Yun, Browning, Sharon R., Browning, Brian L., Slater, Andrew J., Kong, Xiangyang, Aponte, Jennifer L., Mooser, Vincent E., Chissoe, Stephanie L., Whittaker, John C., Nelson, Matthew R., Ehm, Margaret Gelder
Publicado 2011

Characterization of ADME gene variation in 21 populations by exome sequencing

por Hovelson, Daniel H., Xue, Zhengyu, Zawistowski, Matthew, Ehm, Margaret G., Harris, Elizabeth C., Stocker, Sophie L., Gross, Annette S., Jang, In-Jin, Ieiri, Ichiro, Lee, Jong-Eun, Cardon, Lon R., Chissoe, Stephanie L., Abecasis, Gonçalo, Nelson, Matthew R.
Publicado 2017

Phenome-wide association study using research participants’ self-reported data provides insight into the Th17 and IL-17 pathway

por Ehm, Margaret G., Aponte, Jennifer L., Chiano, Mathias N., Yerges-Armstrong, Laura M., Johnson, Toby, Barker, Jonathan N., Cook, Suzanne F., Gupta, Akanksha, Hinds, David A., Li, Li, Nelson, Matthew R., Simpson, Michael A., Tian, Chao, McCarthy, Linda C., Rajpal, Deepak K., Waterworth, Dawn M.
Publicado 2017

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

por Carr, Daniel F., Bourgeois, Stephane, Chaponda, Mas, Takeshita, Louise Y., Morris, Andrew P., Castro, Elena M. Cornejo, Alfirevic, Ana, Jones, Andrew R., Rigden, Daniel J., Haldenby, Sam, Khoo, Saye, Lalloo, David G., Heyderman, Robert S., Dandara, Collet, Kampira, Elizabeth, van Oosterhout, Joep J., Ssali, Francis, Munderi, Paula, Novelli, Giuseppe, Borgiani, Paola, Nelson, Matthew R., Holden, Arthur, Deloukas, Panos, Pirmohamed, Munir
Publicado 2017

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort

por Nicoletti, Paola, Carr, Daniel F., Barrett, Sarah, McEvoy, Laurence, Friedmann, Peter S., Shear, Neil H., Nelson, Matthew R., Chiriac, Anca M., Blanca-López, Natalia, Cornejo-García, José A., Gaeta, Francesco, Nakonechna, Alla, Torres, Maria J., Caruso, Cristiano, Valluzzi, Rocco L., Floratos, Aris, Shen, Yufeng, Pavlos, Rebecca K., Phillips, Elizabeth J., Demoly, Pascal, Romano, Antonino, Blanca, Miguel, Pirmohamed, Munir
Publicado 2021

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation

por Warren, Liling L., Li, Li, Nelson, Matthew R., Ehm, Margaret G., Shen, Judong, Fraser, Dana J., Aponte, Jennifer L., Nangle, Keith L., Slater, Andrew J., Woollard, Peter M., Hall, Matt D., Topp, Simon D., Yuan, Xin, Cardon, Lon R., Chissoe, Stephanie L., Mooser, Vincent, Morris, Andrew D., Palmer, Colin N.A., Perry, John R., Frayling, Timothy M., Whittaker, John C., Waterworth, Dawn M.
Publicado 2012

Shared Genetic Risk Factors Across Carbamazepine‐Induced Hypersensitivity Reactions

por Nicoletti, Paola, Barrett, Sarah, McEvoy, Laurence, Daly, Ann K., Aithal, Guruprasad, Lucena, M. Isabel, Andrade, Raul J., Wadelius, Mia, Hallberg, Pär, Stephens, Camilla, Bjornsson, Einar S., Friedmann, Peter, Kainu, Kati, Laitinen, Tarja, Marson, Anthony, Molokhia, Mariam, Phillips, Elizabeth, Pichler, Werner, Romano, Antonino, Shear, Neil, Sills, Graeme, Tanno, Luciana K., Swale, Ashley, Floratos, Aris, Shen, Yufeng, Nelson, Matthew R., Watkins, Paul B., Daly, Mark J., Morris, Andrew P., Alfirevic, Ana, Pirmohamed, Munir
Publicado 2019

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

por Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.
Publicado 2020

Exome sequencing and characterization of 49,960 individuals in the UK Biobank

por Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris
Publicado 2020