Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol–Ene/Cyclization Sequence in Continuous Flow

por Steiner, Alexander, Nelson, Ryan C., Dallinger, Doris, Kappe, C. Oliver
Publicado 2022

Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol

por Lucas, Tobias, Dietz, Jule-Philipp, Cardoso, Flavio S. P., Snead, David R., Nelson, Ryan C., Donsbach, Kai O., Gupton, B. Frank, Opatz, Till
Publicado 2023

An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly

por Snead, David R., McQuade, D. Tyler, Ahmad, Saeed, Krack, Rudy, Stringham, Rodger W., Burns, Justina M., Abdiaj, Irini, Gopalsamuthiram, Vijayagopal, Nelson, Ryan C., Gupton, B. Frank
Publicado 2020

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline

por Mear, Sarah Jane, Lucas, Tobias, Ahlqvist, Grace P., Robey, Juliana M. S., Dietz, Jule‐Philipp, Khairnar, Pankaj V., Maity, Sanjay, Williams, Corshai L., Snead, David R., Nelson, Ryan C., Opatz, Till, Jamison, Timothy F.
Publicado 2022

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline

por Robey, Juliana M. S., Maity, Sanjay, Aleshire, Sarah L., Ghosh, Angshuman, Yadaw, Ajay K., Roy, Subho, Mear, Sarah Jane, Jamison, Timothy F., Sirasani, Gopal, Senanayake, Chris H., Stringham, Rodger W., Gupton, B. Frank, Donsbach, Kai O., Nelson, Ryan C., Shanahan, Charles S.
Publicado 2023

Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223

por Cardoso, Flavio S.P., Kadam, Appasaheb L., Nelson, Ryan C., Tomlin, John W., Dahal, Dipendra, Kuehner, Christopher S., Gudvangen, Gard, Arduengo, Anthony J., Burns, Justina M., Aleshire, Sarah L., Snead, David R., Qu, Fengrui, Belmore, Ken, Ahmad, Saeed, Agrawal, Toolika, Sieber, Joshua D., Donsbach, Kai Oliver
Publicado 2023