Structural analysis of the putative SARS-CoV-2 primase complex

por Konkolova, Eva, Klima, Martin, Nencka, Radim, Boura, Evzen
Publicado 2020

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

por Krafcikova, Petra, Silhan, Jan, Nencka, Radim, Boura, Evzen
Publicado 2020

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

por Eyer, Luděk, Nencka, Radim, de Clercq, Erik, Seley-Radtke, Katherine, Růžek, Daniel
Publicado 2018

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors

por Šebera, Jakub, Dubankova, Anna, Sychrovský, Vladimír, Ruzek, Daniel, Boura, Evzen, Nencka, Radim
Publicado 2018

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses

por Cihlova, Bara, Huskova, Andrea, Böserle, Jiri, Nencka, Radim, Boura, Evzen, Silhan, Jan
Publicado 2021

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses

por Konkolova, Eva, Dejmek, Milan, Hřebabecký, Hubert, Šála, Michal, Böserle, Jiří, Nencka, Radim, Boura, Evzen
Publicado 2020

Coronaviral RNA-methyltransferases: function, structure and inhibition

por Nencka, Radim, Silhan, Jan, Klima, Martin, Otava, Tomas, Kocek, Hugo, Krafcikova, Petra, Boura, Evzen
Publicado 2022

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

por Dinesh, Dhurvas Chandrasekaran, Chalupska, Dominika, Silhan, Jan, Koutna, Eliska, Nencka, Radim, Veverka, Vaclav, Boura, Evzen
Publicado 2020

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

por Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen
Publicado 2023

The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine

por Šebera, Jakub, Hattori, Yoshikazu, Sato, Daichi, Řeha, David, Nencka, Radim, Kohno, Takashi, Kojima, Chojiro, Tanaka, Yoshiyuki, Sychrovský, Vladimír
Publicado 2017

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication

por Dejmek, Milan, Konkoľová, Eva, Eyer, Luděk, Straková, Petra, Svoboda, Pavel, Šála, Michal, Krejčová, Kateřina, Růžek, Daniel, Boura, Evzen, Nencka, Radim
Publicado 2021

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

por Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen
Publicado 2021

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

por Šála, Michal, Kögler, Martin, Plačková, Pavla, Mejdrová, Ivana, Hřebabecký, Hubert, Procházková, Eliška, Strunin, Dmytro, Lee, Gary, Birkus, Gabriel, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Publicado 2016

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure

por Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim
Publicado 2023

Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein

por Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen
Publicado 2016

Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction

por Nuta, Gal Chaim, Gilad, Yuval, Goldberg, Nadav, Meril, Sara, Bahlsen, Marcela, Carvalho, Silvia, Kozer, Noga, Barr, Haim, Fridmann Sirkis, Yael, Hercík, Kamil, Břehová, Petra, Nencka, Radim, Bialik, Shani, Eisenstein, Miriam, Kimchi, Adi
Publicado 2023

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

por Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Publicado 2023

SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia

por Chambers, Courtney, Cermakova, Katerina, Chan, Yuen San, Kurtz, Kristen, Wohlan, Katharina, Lewis, Andrew Henry, Wang, Christiana, Pham, Anh, Dejmek, Milan, Sala, Michal, Loeza Cabrera, Mario, Aguilar, Rogelio, Nencka, Radim, Lacorazza, H. Daniel, Rau, Rachel E., Hodges, H. Courtney
Publicado 2023

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping

por Břehová, Petra, Řezníčková, Eva, Škach, Kryštof, Jorda, Radek, Dejmek, Milan, Vojáčková, Veronika, Šála, Michal, Kovalová, Markéta, Dračínský, Martin, Dolníková, Alexandra, Strmeň, Timotej, Kinnertová, Monika, Chalupský, Karel, Dvořáková, Alexandra, Gucký, Tomáš, Mertlíková Kaiserová, Helena, Klener, Pavel, Nencka, Radim, Kryštof, Vladimír
Publicado 2023

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

por Kremer, Lea, Hennes, Elisabeth, Brause, Alexandra, Ursu, Andrei, Robke, Lucas, Matsubayashi, Hideaki T., Nihongaki, Yuta, Flegel, Jana, Mejdrová, Ivana, Eickhoff, Jan, Baumann, Matthias, Nencka, Radim, Janning, Petra, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Inoue, Takanari, Ziegler, Slava, Waldmann, Herbert
Publicado 2019