Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

por Lo, Yu-Chen, Cormier, Olga, Liu, Tianyun, Nettles, Kendall W., Katzenellenbogen, John A., Stearns, Tim, Altman, Russ B.
Publicado 2019

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

por Weikum, Emily R., de Vera, Ian Mitchelle S., Nwachukwu, Jerome C., Hudson, William H., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Publicado 2017

OR11-01 A New Model for Estrogen Receptor-alpha Antagonist Mechanism of Action

por Nwachukwu, Jerome C, Njeri, Jacqline W, Venables, Thomas, Seath, Ciaran, Pipkin, Matthew E, Hou, Yingwei, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Nettles, Kendall W
Publicado 2023

Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

por Srinivasan, Sathish, Nwachukwu, Jerome C., Parent, Alex A., Cavett, Valerie, Nowak, Jason, Hughes, Travis S., Kojetin, Douglas J., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2013

Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture

por Yuan, Zixuan, Pavel, Mahmud Arif, Wang, Hao, Kwachukwu, Jerome C., Mediouni, Sonia, Jablonski, Joseph Anthony, Nettles, Kendall W., Reddy, Chakravarthy B., Valente, Susana T., Hansen, Scott B.
Publicado 2022

Author Correction: Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture

por Yuan, Zixuan, Pavel, Mahmud Arif, Wang, Hao, Kwachukwu, Jerome C., Mediouni, Sonia, Jablonski, Joseph Anthony, Nettles, Kendall W., Reddy, Chakravarthy B., Valente, Susana T., Hansen, Scott B.
Publicado 2022

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

por Liao, Zong-Quan, Dong, Chune, Carlson, Kathryn E., Srinivasan, Sathish, Nwachukwu, Jerome C., Chesnut, Robert W., Sharma, Abhishek, Nettles, Kendall W., Katzenellenbogen, John A., Zhou, Hai-Bing
Publicado 2014

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

por Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2010

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

por Hudson, William H., Vera, Ian Mitchelle S. de, Nwachukwu, Jerome C., Weikum, Emily R., Herbst, Austin G., Yang, Qin, Bain, David L., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Publicado 2018

Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting

por Bruno, Nelson E., Nwachukwu, Jerome C., Hughes, David C., Srinivasan, Sathish, Hawkins, Richard, Sturgill, David, Hager, Gordon L., Hurst, Stephen, Sheu, Shey-Shing, Bodine, Sue C., Conkright, Michael D., Nettles, Kendall W.
Publicado 2021

OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain

por Nwachukwu, Jerome, Min, Jian, Srinivasan, Sathish K, Rangarajan, Erumbi, Guillen, Valeria Sanabria, Ziegler, Yvonne, Carlson, Kathryn, Hou, Yingwei, Kim, Sung Hoon, Izard, Tina, Houtman, Rene, Katzenellenbogen, Benita S, Nettles, Kendall W, Katzenellenbogen, John A
Publicado 2020

Predictive features of ligand‐specific signaling through the estrogen receptor

por Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W
Publicado 2016

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

por Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M., Shulman, Andrew I., Rance, Mark, Griffin, Patrick R., Bruning, John B., Nettles, Kendall W.
Publicado 2015

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

por Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W
Publicado 2014

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

por Srinivasan, Sathish, Nwachukwu, Jerome C., Bruno, Nelson E., Dharmarajan, Venkatasubramanian, Goswami, Devrishi, Kastrati, Irida, Novick, Scott, Nowak, Jason, Cavett, Valerie, Zhou, Hai-Bing, Boonmuen, Nittaya, Zhao, Yuechao, Min, Jian, Frasor, Jonna, Katzenellenbogen, Benita S., Griffin, Patrick R., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2016

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

por Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Publicado 2018

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

por Solis, Oscar, Beccari, Andrea R., Iaconis, Daniela, Talarico, Carmine, Ruiz-Bedoya, Camilo A., Nwachukwu, Jerome C., Cimini, Annamaria, Castelli, Vanessa, Bertini, Riccardo, Montopoli, Monica, Cocetta, Veronica, Borocci, Stefano, Prandi, Ingrid G., Flavahan, Kelly, Bahr, Melissa, Napiorkowski, Anna, Chillemi, Giovanni, Ooka, Masato, Yang, Xiaoping, Zhang, Shiliang, Xia, Menghang, Zheng, Wei, Bonaventura, Jordi, Pomper, Martin G., Hooper, Jody E., Morales, Marisela, Rosenberg, Avi Z., Nettles, Kendall W., Jain, Sanjay K., Allegretti, Marcello, Michaelides, Michael
Publicado 2022

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

por Solis, Oscar, Beccari, Andrea R., Iaconis, Daniela, Talarico, Carmine, Ruiz-Bedoya, Camilo A., Nwachukwu, Jerome C., Cimini, Annamaria, Castelli, Vanessa, Bertini, Riccardo, Montopoli, Monica, Cocetta, Veronica, Borocci, Stefano, Prandi, Ingrid G., Flavahan, Kelly, Bahr, Melissa, Napiorkowski, Anna, Chillemi, Giovanni, Ooka, Masato, Yang, Xiaoping, Zhang, Shiliang, Xia, Menghang, Zheng, Wei, Bonaventura, Jordi, Pomper, Martin G., Hooper, Jody E., Morales, Marisela, Rosenberg, Avi Z., Nettles, Kendall W., Jain, Sanjay K., Allegretti, Marcello, Michaelides, Michael
Publicado 2022