ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS

por Zhu, Yi, Prata, Larissa Langhi, Gerdes, Erin Wissler, Netto, Jair, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina
Publicado 2022

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

por Espindola-Netto, Jair Machado, Chini, Claudia C.S., Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N.
Publicado 2017

Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis

por Shi, Bo, Wang, Wenxia, Korman, Benjamin, Kai, Li, Wang, Qianqian, Wei, Jun, Bale, Swarna, Marangoni, Roberta Goncalves, Bhattacharyya, Swati, Miller, Stephen, Xu, Dan, Akbarpour, Mahzad, Cheresh, Paul, Proccissi, Daniele, Gursel, Demirkan, Espindola-Netto, Jair Machado, Chini, Claudia C.S., de Oliveira, Guilherme C., Gudjonsson, Johann E., Chini, Eduardo N., Varga, John
Publicado 2020

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

por Tripathi, Utkarsh, Nchioua, Rayhane, Prata, Larissa G. P. Langhi, Zhu, Yi, Gerdes, Erin O. Wissler, Giorgadze, Nino, Pirtskhalava, Tamar, Parker, Erik, Xue, Ailing, Espindola-Netto, Jair Machado, Stenger, Steffen, Robbins, Paul D., Niedernhofer, Laura J., Dickinson, Stephanie L., Allison, David B., Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes, Tchkonia, Tamar, Kirkland, James L.
Publicado 2021

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

por Zeidler, Julianna D., Chini, Claudia C.S., Kanamori, Karina S., Kashyap, Sonu, Espindola-Netto, Jair M., Thompson, Katie, Warner, Gina, Cabral, Fernanda S., Peclat, Thais R., Gomez, Lilian Sales, Lopez, Sierra A., Wandersee, Miles K., Schoon, Renee A., Reid, Kimberly, Menzies, Keir, Beckedorff, Felipe, Reid, Joel M., Brachs, Sebastian, Meyer, Ralph G., Meyer-Ficca, Mirella L., Chini, Eduardo Nunes
Publicado 2022

Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

por Hayashi, Yujiro, Asuzu, David T., Bardsley, Michael R., Gajdos, Gabriella B., Kvasha, Sergiy M., Linden, David R., Nagy, Rea A., Saravanaperumal, Siva Arumugam, Syed, Sabriya A., Toyomasu, Yoshitaka, Yan, Huihuang, Chini, Eduardo N., Gibbons, Simon J., Kellogg, Todd A., Khazaie, Khashayarsha, Kuro-o, Makoto, Machado Espindola Netto, Jair, Singh, Mahendra Pal, Tidball, James G., Wehling-Henricks, Michelle, Farrugia, Gianrico, Ordog, Tamas
Publicado 2020

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

por Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.
Publicado 2022

Senolytics reduce coronavirus-related mortality in old mice

por Camell, Christina D., Yousefzadeh, Matthew J., Zhu, Yi, Prata, Larissa G. P. Langhi, Huggins, Matthew A., Pierson, Mark, Zhang, Lei, O’Kelly, Ryan D., Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J., Inman, Christina L., Johnson, Kurt O., Cholensky, Stephanie H., Carlson, Timothy W., LeBrasseur, Nathan K., Khosla, Sundeep, O’Sullivan, M. Gerard, Allison, David B., Jameson, Stephen C., Meves, Alexander, Li, Ming, Prakash, Y. S., Chiarella, Sergio E., Hamilton, Sara E., Tchkonia, Tamara, Niedernhofer, Laura J., Kirkland, James L., Robbins, Paul D.
Publicado 2021

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD(+) and NMN levels

por Chini, Claudia C.S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.
Publicado 2020

Apoptotic stress causes mtDNA release during senescence and drives the SASP

por Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.
Publicado 2023