More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances

por Emami Riedmaier, Ariane, Burt, Howard, Abduljalil, Khaled, Neuhoff, Sibylle
Publicado 2016

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic M...

por Doki, Kosuke, Neuhoff, Sibylle, Rostami‐Hodjegan, Amin, Homma, Masato
Publicado 2019

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual s...

por Pan, Xian, Yamazaki, Shinji, Neuhoff, Sibylle, Zhang, Mian, Pilla Reddy, Venkatesh
Publicado 2021

Risk–Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach

por Ezuruike, Udoamaka, Humphries, Helen, Dickins, Maurice, Neuhoff, Sibylle, Gardner, Iain, Rowland Yeo, Karen
Publicado 2018

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

por Emoto, Chie, Johnson, Trevor N., Neuhoff, Sibylle, Hahn, David, Vinks, Alexander A., Fukuda, Tsuyoshi
Publicado 2018

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

por Murata, Yukiko, Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Takita, Hiroyuki, Al-Majdoub, Zubida M., Ogungbenro, Kayode
Publicado 2022

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

por Taggi, Valerio, Riera Romo, Mario, Piquette-Miller, Micheline, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle
Publicado 2022

Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator

por Ezuruike, Udoamaka, Zhang, Mian, Pansari, Amita, De Sousa Mendes, Mailys, Pan, Xian, Neuhoff, Sibylle, Gardner, Iain
Publicado 2022

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

por Burt, Howard J., Riedmaier, Arian Emami, Harwood, Matthew D., Crewe, H. Kim, Gill, Katherine L., Neuhoff, Sibylle
Publicado 2016

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

por Sychterz, Caroline, Gardner, Iain, Chiang, Manting, Rachumallu, Ramakrishna, Neuhoff, Sibylle, Perera, Vidya, Merali, Samira, Schmidt, Brian J., Gaohua, Lu
Publicado 2022

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

por Walsh, Christopher, Bonner, Jennifer J., Johnson, Trevor N., Neuhoff, Sibylle, Ghazaly, Essam A., Gribben, John G., Boddy, Alan V., Veal, Gareth J.
Publicado 2016

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interaction...

por Antonescu, Irina E., Karlgren, Maria, Pedersen, Maria L., Simoff, Ivailo, Bergström, Christel A. S., Neuhoff, Sibylle, Artursson, Per, Steffansen, Bente, Nielsen, Carsten Uhd
Publicado 2020

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

por Kilford, Peter J., Chen, Kuan‐Fu, Crewe, Kim, Gardner, Iain, Hatley, Oliver, Ke, Alice Ban, Neuhoff, Sibylle, Zhang, Mian, Rowland Yeo, Karen
Publicado 2022

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

por Murphy, William A., Adiwidjaja, Jeffry, Sjöstedt, Noora, Yang, Kyunghee, Beaudoin, James J., Spires, Jessica, Siler, Scott Q., Neuhoff, Sibylle, Brouwer, Kim L.R.
Publicado 2022

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

por Tan, Ming‐Liang, Zhao, Ping, Zhang, Lei, Ho, Yunn‐Fang, Varma, Manthena V.S., Neuhoff, Sibylle, Nolin, Thomas D., Galetin, Aleksandra, Huang, Shiew‐Mei
Publicado 2018

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

por Harwood, Matthew D., Zettl, Katharina, Weinheimer, Manuel, Pilla-Reddy, Venkatesh, Shen, Hong, Jacobs, Frank, Chu, Xiaoyan, Huth, Felix, Nakakariya, Masanori, Chothe, Paresh P., Neuhoff, Sibylle, Wiśniewski, Jacek R.
Publicado 2023

Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin

por Al‐Majdoub, Zubida M., Achour, Brahim, Couto, Narciso, Howard, Martyn, Elmorsi, Yasmine, Scotcher, Daniel, Alrubia, Sarah, El‐Khateeb, Eman, Vasilogianni, Areti‐Maria, Alohali, Noura, Neuhoff, Sibylle, Schmitt, Lutz, Rostami‐Hodjegan, Amin, Barber, Jill
Publicado 2020

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

por Brouwer, Kim L.R., Evers, Raymond, Hayden, Elizabeth, Hu, Shuiying, Li, Cindy Yanfei, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle, Oswald, Stefan, Piquette‐Miller, Micheline, Saran, Chitra, Sjöstedt, Noora, Sprowl, Jason A., Stahl, Simone H., Yue, Wei
Publicado 2022

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Reco...

por Taskar, Kunal S., Pilla Reddy, Venkatesh, Burt, Howard, Posada, Maria M., Varma, Manthena, Zheng, Ming, Ullah, Mohammed, Emami Riedmaier, Arian, Umehara, Ken‐ichi, Snoeys, Jan, Nakakariya, Masanori, Chu, Xiaoyan, Beneton, Maud, Chen, Yuan, Huth, Felix, Narayanan, Rangaraj, Mukherjee, Dwaipayan, Dixit, Vaishali, Sugiyama, Yuichi, Neuhoff, Sibylle
Publicado 2019