Human endogenous retroviruses of the HERV-K (HML-2) family are expressed in the brain of healthy individuals and modify the composition of the brain-infiltrating immune cells

por Nevalainen, Tapio, Autio, Arttu, Hurme, Mikko
Publicado 2023

Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging

por Nevalainen, Tapio, Autio, Arttu, Hurme, Mikko
Publicado 2022

Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging

por Autio, Arttu, Kettunen, Jalmari, Nevalainen, Tapio, Kimura, Bryn, Hurme, Mikko
Publicado 2022

Aging-associated patterns in the expression of human endogenous retroviruses

por Nevalainen, Tapio, Autio, Arttu, Mishra, Binisha Hamal, Marttila, Saara, Jylhä, Marja, Hurme, Mikko
Publicado 2018

Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22

por Autio, Arttu, Nevalainen, Tapio, Mishra, Binisha H., Jylhä, Marja, Flinck, Heini, Hurme, Mikko
Publicado 2020

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny

por Marttila, Saara, Kananen, Laura, Jylhävä, Juulia, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Hurme, Mikko
Publicado 2015

Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals

por Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Jylhä, Marja, Hervonen, Antti, Hurme, Mikko
Publicado 2016

CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males

por Nevalainen, Tapio, Autio, Arttu, Kummola, Laura, Salomaa, Tanja, Junttila, Ilkka, Jylhä, Marja, Hurme, Mikko
Publicado 2019

Number of sons contributes to ageing-associated inflammation

por Marttila, Saara, Nevalainen, Tapio, Kananen, Laura, Jylhävä, Juulia, Jylhä, Marja, Hervonen, Antti, Ilonen, Jorma, Hurme, Mikko
Publicado 2015

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift

por Jylhävä, Juulia, Kananen, Laura, Raitanen, Jani, Marttila, Saara, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Hurme, Mikko
Publicado 2016

Transcriptional Analysis Reveals Gender-Specific Changes in the Aging of the Human Immune System

por Marttila, Saara, Jylhävä, Juulia, Nevalainen, Tapio, Nykter, Matti, Jylhä, Marja, Hervonen, Antti, Tserel, Liina, Peterson, Pärt, Hurme, Mikko
Publicado 2013

Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

por Marttila, Saara, Kananen, Laura, Häyrynen, Sergei, Jylhävä, Juulia, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Nykter, Matti, Hurme, Mikko
Publicado 2015

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)

por Savinainen, Juha R., Patel, Jayendra Z., Parkkari, Teija, Navia-Paldanius, Dina, Marjamaa, Joona J. T., Laitinen, Tuomo, Nevalainen, Tapio, Laitinen, Jarmo T.
Publicado 2014

Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors

por Kaczor, Agnieszka A., Targowska-Duda, Katarzyna M., Patel, Jayendra Z., Laitinen, Tuomo, Parkkari, Teija, Adams, Yahaya, Nevalainen, Tapio J., Poso, Antti
Publicado 2015

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals

por Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Mononen, Nina, Kähönen, Mika, Raitakari, Olli T., Hervonen, Antti, Jylhä, Marja, Lehtimäki, Terho, Hurme, Mikko
Publicado 2017

Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)

por Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R., Laitinen, Jarmo T.
Publicado 2014