Pioneer cells established by the [SWI(+)] prion can promote dispersal and out-crossing in yeast

por Newby, Gregory A., Lindquist, Susan
Publicado 2017

Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors

por Doman, Jordan L., Raguram, Aditya, Newby, Gregory A., Liu, David R.
Publicado 2020

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

por Krishnamurthy, Sateesh, Traore, Soumba, Cooney, Ashley L, Brommel, Christian M, Kulhankova, Katarina, Sinn, Patrick L, Newby, Gregory A, Liu, David R, McCray, Paul B
Publicado 2021

Continuous evolution of SpCas9 variants compatible with non-G PAMs

por Miller, Shannon M., Wang, Tina, Randolph, Peyton B., Arbab, Mandana, Shen, Max W., Huang, Tony P., Matuszek, Zaneta, Newby, Gregory A., Rees, Holly A., Liu, David R.
Publicado 2020

Continuous evolution of base editors with expanded target compatibility and improved activity

por Thuronyi, Benjamin W., Koblan, Luke W., Levy, Jonathan M., Yeh, Wei-Hsi, Zheng, Christine, Newby, Gregory A., Wilson, Christopher, Bhaumik, Mantu, Shubina-Oleinik, Olga, Holt, Jeffrey R., Liu, David R.
Publicado 2019

Engineered pegRNAs improve prime editing efficiency

por Nelson, James W., Randolph, Peyton B., Shen, Simon P., Everette, Kelcee A., Chen, Peter J., Anzalone, Andrew V., An, Meirui, Newby, Gregory A., Chen, Jonathan C., Hsu, Alvin, Liu, David R.
Publicado 2022

Search-and-replace genome editing without double-strand breaks or donor DNA

por Anzalone, Andrew V., Randolph, Peyton B., Davis, Jessie R., Sousa, Alexander A., Koblan, Luke W., Levy, Jonathan M., Chen, Peter J., Wilson, Christopher, Newby, Gregory A., Raguram, Aditya, Liu, David R.
Publicado 2019

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

por Richter, Michelle F., Zhao, Kevin T., Eton, Elliot, Lapinaite, Audrone, Newby, Gregory A., Thuronyi, Benjamin W., Wilson, Christopher, Koblan, Luke W., Zeng, Jing, Bauer, Daniel E., Doudna, Jennifer A., Liu, David R.
Publicado 2020

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

por Chen, Peter J., Hussmann, Jeffrey A., Yan, Jun, Knipping, Friederike, Ravisankar, Purnima, Chen, Pin-Fang, Chen, Cidi, Nelson, James W., Newby, Gregory A., Sahin, Mustafa, Osborn, Mark J., Weissman, Jonathan S., Adamson, Britt, Liu, David R.
Publicado 2021

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

por Banskota, Samagya, Raguram, Aditya, Suh, Susie, Du, Samuel W., Davis, Jessie R., Choi, Elliot H., Wang, Xiao, Nielsen, Sarah C., Newby, Gregory A., Randolph, Peyton B., Osborn, Mark J., Musunuru, Kiran, Palczewski, Krzysztof, Liu, David R.
Publicado 2022

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

por Zhang, Han, Kelly, Karen, Lee, Jonathan, Echeverria, Dimas, Cooper, David, Panwala, Rebecca, Chen, Zexiang, Gaston, Nicholas, Newby, Gregory A., Xie, Jun, Liu, David R., Gao, Guangping, Wolfe, Scot A., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.
Publicado 2023

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

por Neugebauer, Monica E., Hsu, Alvin, Arbab, Mandana, Krasnow, Nicholas A., McElroy, Amber N., Pandey, Smriti, Doman, Jordan L., Huang, Tony P., Raguram, Aditya, Banskota, Samagya, Newby, Gregory A., Tolar, Jakub, Osborn, Mark J., Liu, David R.
Publicado 2022

In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies

por Li, Chang, Georgakopoulou, Aphrodite, Newby, Gregory A., Everette, Kelcee A., Nizamis, Evangelos, Paschoudi, Kiriaki, Vlachaki, Efthymia, Gil, Sucheol, Anderson, Anna K., Koob, Theodore, Huang, Lishan, Wang, Hongjie, Kiem, Hans-Peter, Liu, David R., Yannaki, Evangelia, Lieber, André
Publicado 2022

In vivo HSC prime editing rescues sickle cell disease in a mouse model

por Li, Chang, Georgakopoulou, Aphrodite, Newby, Gregory A., Chen, Peter J., Everette, Kelcee A., Paschoudi, Kiriaki, Vlachaki, Efthymia, Gil, Sucheol, Anderson, Anna K., Koob, Theodore, Huang, Lishan, Wang, Hongjie, Kiem, Hans-Peter, Liu, David R., Yannaki, Evangelia, Lieber, André
Publicado 2023

Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells

por Joynt, Anya T., Kavanagh, Erin W., Newby, Gregory A., Mitchell, Shakela, Eastman, Alice C., Paul, Kathleen C., Bowling, Alyssa D., Osorio, Derek L., Merlo, Christian A., Patel, Shivani U., Raraigh, Karen S., Liu, David R., Sharma, Neeraj, Cutting, Garry R.
Publicado 2023

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

por Choi, Elliot H., Suh, Susie, Foik, Andrzej T., Leinonen, Henri, Newby, Gregory A., Gao, Xin D., Banskota, Samagya, Hoang, Thanh, Du, Samuel W., Dong, Zhiqian, Raguram, Aditya, Kohli, Sajeev, Blackshaw, Seth, Lyon, David C., Liu, David R., Palczewski, Krzysztof
Publicado 2022

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

por Kabra, Meha, Shahi, Pawan K., Wang, Yuyuan, Sinha, Divya, Spillane, Allison, Newby, Gregory A., Saxena, Shivani, Tong, Yao, Chang, Yu, Abdeen, Amr A., Edwards, Kimberly L., Theisen, Cole O., Liu, David R., Gamm, David M., Gong, Shaoqin, Saha, Krishanu, Pattnaik, Bikash R.
Publicado 2023

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

por Jiang, Tingting, Henderson, Jordana M., Coote, Kevin, Cheng, Yi, Valley, Hillary C., Zhang, Xiao-Ou, Wang, Qin, Rhym, Luke H., Cao, Yueying, Newby, Gregory A., Bihler, Hermann, Mense, Martin, Weng, Zhiping, Anderson, Daniel G., McCaffrey, Anton P., Liu, David R., Xue, Wen
Publicado 2020

Base editing rescue of spinal muscular atrophy in cells and in mice

por Arbab, Mandana, Matuszek, Zaneta, Kray, Kaitlyn M., Du, Ailing, Newby, Gregory A., Blatnik, Anton J., Raguram, Aditya, Richter, Michelle F., Zhao, Kevin T., Levy, Jonathan M., Shen, Max W., Arnold, W. David, Wang, Dan, Xie, Jun, Gao, Guangping, Burghes, Arthur H. M., Liu, David R.
Publicado 2023

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

por Reichart, Daniel, Newby, Gregory A., Wakimoto, Hiroko, Lun, Mingyue, Gorham, Joshua M., Curran, Justin J., Raguram, Aditya, DeLaughter, Daniel M., Conner, David A., Marsiglia, Júlia D. C., Kohli, Sajeev, Chmatal, Lukas, Page, David C., Zabaleta, Nerea, Vandenberghe, Luk, Liu, David R., Seidman, Jonathan G., Seidman, Christine
Publicado 2023