Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

por Pittet, Camille L, Newcombe, Jia, Prat, Alexandre, Arbour, Nathalie
Publicado 2011

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

por Fischer, Iris, Alliod, Chantal, Martinier, Nicolas, Newcombe, Jia, Brana, Corinne, Pouly, Sandrine
Publicado 2011

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS

por Tyzack, Giulia E, Manferrari, Giulia, Newcombe, Jia, Luscombe, Nicholas M, Luisier, Raphaelle, Patani, Rickie
Publicado 2020

In vitro prion-like behaviour of TDP-43 in ALS

por Smethurst, Phillip, Newcombe, Jia, Troakes, Claire, Simone, Roberto, Chen, Yun-Ru, Patani, Rickie, Sidle, Katie
Publicado 2016

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

por Tzartos, John S., Craner, Matthew J., Friese, Manuel A., Jakobsen, Karen B., Newcombe, Jia, Esiri, Margaret M., Fugger, Lars
Publicado 2011

STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases

por Ferecskó, Alex S., Smallwood, Miranda J., Moore, Adrian, Liddle, Corin, Newcombe, Jia, Holley, Janet, Whatmore, Jacqueline, Gutowski, Nicholas J., Eggleton, Paul
Publicado 2023

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

por Hagemann, Cathleen, Tyzack, Giulia E., Taha, Doaa M., Devine, Helen, Greensmith, Linda, Newcombe, Jia, Patani, Rickie, Serio, Andrea, Luisier, Raphaëlle
Publicado 2021

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

por Colombo, Emanuela, Cordiglieri, Chiara, Melli, Giorgia, Newcombe, Jia, Krumbholz, Markus, Parada, Luis F., Medico, Enzo, Hohlfeld, Reinhard, Meinl, Edgar, Farina, Cinthia
Publicado 2012

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

por Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie
Publicado 2020

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

por Tyzack, Giulia E, Luisier, Raphaelle, Taha, Doaa M, Neeves, Jacob, Modic, Miha, Mitchell, Jamie S, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M, Patani, Rickie
Publicado 2019

Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination

por Iacobaeus, Ellen, Sugars, Rachael V., Törnqvist Andrén, Anton, Alm, Jessica J., Qian, Hong, Frantzen, Janek, Newcombe, Jia, Alkass, Kanar, Druid, Henrik, Bottai, Matteo, Röyttä, Matias, Le Blanc, Katarina
Publicado 2017

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

por Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Publicado 2018

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

por Tyzack, Giulia E., Hall, Claire E., Sibley, Christopher R., Cymes, Tomasz, Forostyak, Serhiy, Carlino, Giulia, Meyer, Ione F., Schiavo, Giampietro, Zhang, Su-Chun, Gibbons, George M., Newcombe, Jia, Patani, Rickie, Lakatos, András
Publicado 2017

Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?

por Grussu, Francesco, Schneider, Torben, Tur, Carmen, Yates, Richard L., Tachrount, Mohamed, Ianuş, Andrada, Yiannakas, Marios C., Newcombe, Jia, Zhang, Hui, Alexander, Daniel C., DeLuca, Gabriele C., Gandini Wheeler‐Kingshott, Claudia A. M.
Publicado 2017

JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

por Rivellini, Cristina, Porrello, Emanuela, Dina, Giorgia, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Bacigaluppi, Marco, Gullotta, Giorgia Serena, Chaabane, Linda, Leocani, Letizia, Marenna, Silvia, Colombo, Emanuela, Farina, Cinthia, Newcombe, Jia, Nave, Klaus-Armin, Pardi, Ruggero, Quattrini, Angelo, Previtali, Stefano C.
Publicado 2022

Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion()

por Fratta, Pietro, Polke, James M., Newcombe, Jia, Mizielinska, Sarah, Lashley, Tammaryn, Poulter, Mark, Beck, Jon, Preza, Elisavet, Devoy, Anny, Sidle, Katie, Howard, Robin, Malaspina, Andrea, Orrell, Richard W., Clarke, Jan, Lu, Ching-Hua, Mok, Kin, Collins, Toby, Shoaii, Maryam, Nanji, Tina, Wray, Selina, Adamson, Gary, Pittman, Alan, Renton, Alan E., Traynor, Bryan J., Sweeney, Mary G., Revesz, Tamas, Houlden, Henry, Mead, Simon, Isaacs, Adrian M., Fisher, Elizabeth M.C.
Publicado 2015

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

por Brown, Anna-Leigh, Wilkins, Oscar G., Keuss, Matthew J., Hill, Sarah E., Zanovello, Matteo, Lee, Weaverly Colleen, Bampton, Alexander, Lee, Flora C. Y., Masino, Laura, Qi, Yue A., Bryce-Smith, Sam, Gatt, Ariana, Hallegger, Martina, Fagegaltier, Delphine, Phatnani, Hemali, Newcombe, Jia, Gustavsson, Emil K., Seddighi, Sahba, Reyes, Joel F., Coon, Steven L., Ramos, Daniel, Schiavo, Giampietro, Fisher, Elizabeth M. C., Raj, Towfique, Secrier, Maria, Lashley, Tammaryn, Ule, Jernej, Buratti, Emanuele, Humphrey, Jack, Ward, Michael E., Fratta, Pietro
Publicado 2022