RecQ helicases in DNA repair and cancer targets

por Newman, Joseph A., Gileadi, Opher
Publicado 2020

Exploring the role of SlrR and SlrA in the SinR epigenetic switch

por Newman, Joseph A, Lewis, Richard J
Publicado 2013

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug developme...

por Imprachim, Nergis, Yosaatmadja, Yuliana, Newman, Joseph A
Publicado 2022

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

por Cooper, Christopher D.O., Newman, Joseph A., Gileadi, Opher
Publicado 2014

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

por Newman, Joseph A., Aitkenhead, Hazel, Savitsky, Pavel, Gileadi, Opher
Publicado 2017

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2

por Newman, Joseph A, Cooper, Christopher D. O., Aitkenhead, Hazel, Gileadi, Opher
Publicado 2015

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

por Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher
Publicado 2015

Cloning, purification and preliminary crystallographic analysis of a putative pyridoxal kinase from Bacillus subtilis

por Newman, Joseph A., Das, Sanjan K., Sedelnikova, Svetlana E., Rice, David W.
Publicado 2006

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION

por Cooper, Christopher D. O., Newman, Joseph A., Aitkenhead, Hazel, Allerston, Charles K., Gileadi, Opher
Publicado 2015

The SNM1A DNA repair nuclease

por Baddock, Hannah T., Yosaatmadja, Yuliana, Newman, Joseph A., Schofield, Christopher J., Gileadi, Opher, McHugh, Peter J.
Publicado 2020

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

por Allerston, Charles K., Lee, Sook Y., Newman, Joseph A., Schofield, Christopher J., McHugh, Peter J., Gileadi, Opher
Publicado 2015

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

por Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Publicado 2021

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

por Newman, Joseph A., Aitkenhead, Hazel, Gavard, Angeline E., Rota, Ioanna A., Handel, Adam E., Hollander, Georg A., Gileadi, Opher
Publicado 2020

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

por Lim, Michael, Newman, Joseph A., Williams, Hannah L., Masino, Laura, Aitkenhead, Hazel, Gravard, Angeline E., Gileadi, Opher, Svejstrup, Jesper Q.
Publicado 2019

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

por Newman, Joseph A., Cooper, Christopher D. O., Roos, Anette K., Aitkenhead, Hazel, Oppermann, Udo C. T., Cho, Hearn J., Osman, Roman, Gileadi, Opher
Publicado 2016

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

por Na, Juri, Newman, Joseph A., Then, Chee Kin, Syed, Junetha, Vendrell, Iolanda, Torrecilla, Ignacio, Ellermann, Sophie, Ramadan, Kristijan, Fischer, Roman, Kiltie, Anne E.
Publicado 2021

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

por Newman, Joseph A., Savitsky, Pavel, Allerston, Charles K., Bizard, Anna H., Özer, Özgün, Sarlós, Kata, Liu, Ying, Pardon, Els, Steyaert, Jan, Hickson, Ian D., Gileadi, Opher
Publicado 2015

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

por Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher
Publicado 2021

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

por Newman, Joseph A, Gavard, Angeline E, Lieb, Simone, Ravichandran, Madhwesh C, Hauer, Katja, Werni, Patrick, Geist, Leonhard, Böttcher, Jark, Engen, John R, Rumpel, Klaus, Samwer, Matthias, Petronczki, Mark, Gileadi, Opher
Publicado 2020

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

por Newman, Joseph A., Douangamath, Alice, Yadzani, Setayesh, Yosaatmadja, Yuliana, Aimon, Antony, Brandão-Neto, José, Dunnett, Louise, Gorrie-stone, Tyler, Skyner, Rachael, Fearon, Daren, Schapira, Matthieu, von Delft, Frank, Gileadi, Opher
Publicado 2021