Biochemical Characterization of the Phosphatase Domain of the Tumor Suppressor PH Domain Leucine-Rich Repeat Protein Phosphatase

por Sierecki, Emma, Newton, Alexandra C.
Publicado 2014

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

por Lordén, Gema, Newton, Alexandra C.
Publicado 2021

Protein kinase C showcases allosteric control: activation of LRRK1

por Tovell, Hannah, Newton, Alexandra C.
Publicado 2023

Shedding light on local kinase activation

por Scott, John D, Newton, Alexandra C
Publicado 2012

Conventional protein kinase C in the brain: 40 years later

por Callender, Julia A., Newton, Alexandra C.
Publicado 2017

Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration

por Pilo, Caila A., Newton, Alexandra C.
Publicado 2022

PKCα Is Recruited to Staphylococcus aureus-Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy

por Gauron, Maria Celeste, Newton, Alexandra C., Colombo, María Isabel
Publicado 2021

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

por Violin, Jonathan D., Zhang, Jin, Tsien, Roger Y., Newton, Alexandra C.
Publicado 2003

Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

por Sierecki, Emma, Sinko, William, McCammon, J. Andrew, Newton, Alexandra C.
Publicado 2010

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)

por Keshwani, Malik M., von Daake, Sventja, Newton, Alexandra C., Harris, Thomas K., Taylor, Susan S.
Publicado 2011

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

por Jones, Alexander C., Kornev, Alexandr P., Weng, Jui-Hung, Manning, Gerard, Taylor, Susan S., Newton, Alexandra C.
Publicado 2023

Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation

por Jung, Hae-Yun, Fattet, Laurent, Tsai, Jeff H., Kajimoto, Taketoshi, Chang, Qiang, Newton, Alexandra C., Yang, Jing
Publicado 2019

Protein kinase C fusion proteins are paradoxically loss of function in cancer

por Van, An-Angela N., Kunkel, Maya T., Baffi, Timothy R., Lordén, Gema, Antal, Corina E., Banerjee, Sourav, Newton, Alexandra C.
Publicado 2021

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

por Cohen Katsenelson, Ksenya, Stender, Joshua D, Kawashima, Agnieszka T, Lordén, Gema, Uchiyama, Satoshi, Nizet, Victor, Glass, Christopher K, Newton, Alexandra C
Publicado 2019

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

por Zhou, Xin, Zhong, Yanghao, Molinar-Inglis, Olivia, Kunkel, Maya T., Chen, Mingyuan, Sun, Tengqian, Zhang, Jiao, Shyy, John Y.-J., Trejo, JoAnn, Newton, Alexandra C., Zhang, Jin
Publicado 2020

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

por Lordén, Gema, Wozniak, Jacob M., Doré, Kim, Dozier, Lara E., Cates-Gatto, Chelsea, Patrick, Gentry N., Gonzalez, David J., Roberts, Amanda J., Tanzi, Rudolph E., Newton, Alexandra C.
Publicado 2022

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival

por Dowling, Catríona M., Phelan, James, Callender, Julia A., Cathcart, Mary Clare, Mehigan, Brian, McCormick, Paul, Dalton, Tara, Coffey, John C., Newton, Alexandra C., O'sullivan, Jacintha, Kiely, Patrick A.
Publicado 2016

PKA, PKC, and AKAP localization in and around the neuromuscular junction

por Perkins, Guy A, Wang, Lin, Huang, Lily Jun-shen, Humphries, Kenneth, Yao, Virginia J, Martone, Maryann, Deerinck, Thomas J, Barraclough, David M, Violin, Jonathan D, Smith, Donelson, Newton, Alexandra, Scott, John D, Taylor, Susan S, Ellisman, Mark H
Publicado 2001

Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources

por Huang, Liang-Chin, Ross, Karen E., Baffi, Timothy R., Drabkin, Harold, Kochut, Krzysztof J., Ruan, Zheng, D’Eustachio, Peter, McSkimming, Daniel, Arighi, Cecilia, Chen, Chuming, Natale, Darren A., Smith, Cynthia, Gaudet, Pascale, Newton, Alexandra C., Wu, Cathy, Kannan, Natarajan
Publicado 2018

The PHLPP2 phosphatase is a druggable driver of prostate cancer progression

por Nowak, Dawid G., Katsenelson, Ksenya Cohen, Watrud, Kaitlin E., Chen, Muhan, Mathew, Grinu, D’Andrea, Vincent D., Lee, Matthew F., Swamynathan, Manojit Mosur, Casanova-Salas, Irene, Jibilian, Megan C., Buckholtz, Caroline L., Ambrico, Alexandra J., Pan, Chun-Hao, Wilkinson, John E., Newton, Alexandra C., Trotman, Lloyd C.
Publicado 2019