Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design

por Zhang, Jihui, Chen, Jie, Newton, Gary K., Perrior, Trevor R., Robinson, Clive
Publicado 2018

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens

por Zhang, Jihui, Chen, Jie, Zuo, Jie, Newton, Gary K., Stewart, Mark R., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2018

Presentation blood glucose and death, hospitalization, and future diabetes risk in patients with acute heart failure syndromes

por Sud, Maneesh, Wang, Xuesong, Austin, Peter C., Lipscombe, Lorraine L., Newton, Gary E., Tu, Jack V., Vasan, Ramachandran S., Lee, Douglas S.
Publicado 2015

Inverse relationship of subjective daytime sleepiness to mortality in heart failure patients with sleep apnoea

por Kasai, Takatoshi, Taranto Montemurro, Luigi, Yumino, Dai, Wang, Hanqiao, Floras, John S., Newton, Gary E., Mak, Susanna, Ruttanaumpawan, Pimon, Parker, John D., Bradley, T. Douglas
Publicado 2020

Prediction of Emergent Heart Failure Death by Semi-Quantitative Triage Risk Stratification

por Van Spall, Harriette G. C., Atzema, Clare, Schull, Michael J., Newton, Gary E., Mak, Susanna, Chong, Alice, Tu, Jack V., Stukel, Thérèse A., Lee, Douglas S.
Publicado 2011

Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4

por Golforoush, Pelin A., Narasimhan, Priyanka, Chaves-Guerrero, Patricia P., Lawrence, Elsa, Newton, Gary, Yan, Robert, Harding, Sian E., Perrior, Trevor, Chapman, Kathryn L., Schneider, Michael D.
Publicado 2020

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

por te Lintel Hekkert , Maaike, Newton, Gary, Chapman, Kathryn, Aqil, Rehan, Downham, Robert, Yan, Robert, Merkus, Daphne, Whitlock, Gavin, Lane, Charlotte A. L., Cawkill, Darren, Perrior, Trevor, Duncker, Dirk J., Schneider, Michael D.
Publicado 2021

The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

por Newton, Gary K., Perrior, Trevor R., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark R., Firth-Clark, Stuart, Lloyd, Steven M., Zhang, Jihui, Francis-Newton, Nicola J., Richardson, Jonathan P., Chen, Jie, Lai, Pei, Garrod, David R., Robinson, Clive
Publicado 2014

Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy

por Zhang, Jihui, Chen, Jie, Richardson, Jonathan P., Francis-Newton, Nicola-Jane, Lai, Pei F., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark E., Firth-Clark, Stuart, Lloyd, Steven M., Newton, Gary K., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2022

Determination of Ligand-Binding Affinity (K(d)) Using Transverse Relaxation Rate (R(2)) in the Ligand-Observed (1)H NMR Experiment and Applications to Fragment-Based Drug Discovery

por Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen
Publicado 2023

Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine

por Mehta, Sangeeta, Granton, John, Gordon, Anthony C, Cook, Deborah J, Lapinsky, Stephen, Newton, Gary, Bandayrel, Kris, Little, Anjuli, Siau, Chuin, Ayers, Dieter, Singer, Joel, Lee, Terry CK, Walley, Keith R, Storms, Michelle, Cooper, D James, Holmes, Cheryl L, Hebert, Paul, Presneill, Jeffrey, Russell, James A
Publicado 2013

Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine

por Mehta, Sangeeta, Granton, John, Gordon, Anthony C., Cook, Deborah J., Lapinsky, Stephen, Newton, Gary, Bandayrel, Kris, Little, Anjuli, Siau, Chuin, Ayers, Dieter, Singer, Joel, Lee, Terry C. K., Walley, Keith R., Storms, Michelle, Cooper, D. James, Holmes, Cheryl L., Hebert, Paul, Presneill, Jeffrey, Russell, James A.
Publicado 2017

Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1

por Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.
Publicado 2021

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

por Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimham, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.
Publicado 2019

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

por Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.
Publicado 2020