Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design

por Zhang, Jihui, Chen, Jie, Newton, Gary K., Perrior, Trevor R., Robinson, Clive
Publicado 2018

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens

por Zhang, Jihui, Chen, Jie, Zuo, Jie, Newton, Gary K., Stewart, Mark R., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2018

The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

por Newton, Gary K., Perrior, Trevor R., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark R., Firth-Clark, Stuart, Lloyd, Steven M., Zhang, Jihui, Francis-Newton, Nicola J., Richardson, Jonathan P., Chen, Jie, Lai, Pei, Garrod, David R., Robinson, Clive
Publicado 2014

Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy

por Zhang, Jihui, Chen, Jie, Richardson, Jonathan P., Francis-Newton, Nicola-Jane, Lai, Pei F., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark E., Firth-Clark, Stuart, Lloyd, Steven M., Newton, Gary K., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2022

Determination of Ligand-Binding Affinity (K(d)) Using Transverse Relaxation Rate (R(2)) in the Ligand-Observed (1)H NMR Experiment and Applications to Fragment-Based Drug Discovery

por Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen
Publicado 2023