The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF

por Yuan, Jimin, Ng, Wan Hwa, Yap, Jiajun, Chia, Brandon, Huang, Xuchao, Wang, Mei, Hu, Jiancheng
Publicado 2018

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

por Yuan, Jimin, Ng, Wan Hwa, Lam, Paula Y. P., Wang, Yu, Xia, Hongping, Yap, Jiajun, Guan, Shou Ping, Lee, Ann S. G., Wang, Mei, Baccarini, Manuela, Hu, Jiancheng
Publicado 2018

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop

por Yap, Jiajun, Deepak, R. N. V. Krishna, Tian, Zizi, Ng, Wan Hwa, Goh, Kah Chun, Foo, Alicia, Tee, Zi Heng, Mohanam, Manju Payini, Sim, Yuen Rong M., Degirmenci, Ufuk, Lam, Paula, Chen, Zhongzhou, Fan, Hao, Hu, Jiancheng
Publicado 2021

BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

por Yap, Jiajun, Yuan, Jimin, Ng, Wan Hwa, Chen, Gao Bin, Sim, Yuen Rong M., Goh, Kah Chun, Teo, Joey, Lim, Trixie Y. H., Goay, Shee Min, Teo, Jia Hao Jackie, Lao, Zhentang, Lam, Paula, Sabapathy, Kanaga, Hu, Jiancheng
Publicado 2023