NELF‐A controls Drosophila healthspan by regulating heat‐shock protein‐mediated cellular protection and heterochromatin maintenance

por Ngian, Zhen‐Kai, Lin, Wei‐Qi, Ong, Chin‐Tong
Publicado 2021

Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila

por Lin, Wei-Qi, Ngian, Zhen-Kai, Koh, Tong-Wey, Ong, Chin-Tong
Publicado 2022

Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease

por Adusumalli, Swarnaseetha, Ngian, Zhen‐Kai, Lin, Wei‐Qi, Benoukraf, Touati, Ong, Chin‐Tong
Publicado 2019

Truncated Tau caused by intron retention is enriched in Alzheimer’s disease cortex and exhibits altered biochemical properties

por Ngian, Zhen-Kai, Tan, Yow-Yong, Choo, Ching-Thong, Lin, Wei-Qi, Leow, Chao-Yong, Mah, Shan-Jie, Lai, Mitchell Kim-Peng, Chen, Christopher Li-Hsian, Ong, Chin-Tong
Publicado 2022

E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity

por Yoon, Jeehyun, Grinchuk, Oleg V., Tirado-Magallanes, Roberto, Ngian, Zhen Kai, Tay, Emmy Xue Yun, Chuah, You Heng, Lee, Bernice Woon Li, Feng, Jia, Crasta, Karen Carmelina, Ong, Chin Tong, Benoukraf, Touati, Ong, Derrick Sek Tong
Publicado 2022

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

por Aron, Liviu, Qiu, Chenxi, Ngian, Zhen Kai, Liang, Marianna, Drake, Derek, Choi, Jaejoon, Fernandez, Marty A., Roche, Perle, Bunting, Emma L., Lacey, Ella K., Hamplova, Sara E., Yuan, Monlan, Wolfe, Michael S., Bennett, David A., Lee, Eunjung A., Yankner, Bruce A.
Publicado 2023