Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

por Abskharon, Romany, Sawaya, Michael R., Boyer, David R., Cao, Qin, Nguyen, Binh A., Cascio, Duilio, Eisenberg, David S.
Publicado 2022

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

por Balana, Aaron T., Mahul-Mellier, Anne-Laure, Nguyen, Binh A, Horvath, Mian, Javed, Afraah, Hard, Eldon R., Jasiqi, Yllza, Singh, Preeti, Afrin, Shumaila, Pedretti, Rose, Singh, Virender, Lee, Virginia M.-Y., Luk, Kelvin C., Saelices, Lorena, Lashuel, Hilal A., Pratt, Matthew R.
Publicado 2023

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils

por Abskharon, Romany, Pan, Hope, Sawaya, Michael R., Seidler, Paul M., Olivares, Eileen J., Chen, Yu, Murray, Kevin A., Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R., Cascio, Duilio, Nguyen, Binh A., Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K., Nana, Alissa L., Vinters, Harry V., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Steyaert, Jan, Glabe, Charles G., Ogorzalek Loo, Rachel R., Loo, Joseph A., Eisenberg, David S.
Publicado 2023