Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

por Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Publicado 2013

Nonclinical Development of SRK-181: An Anti-Latent TGFβ1 Monoclonal Antibody for the Treatment of Locally Advanced or Metastatic Solid Tumors

por Welsh, Brian T., Faucette, Ryan, Bilic, Sanela, Martin, Constance J., Schürpf, Thomas, Chen, David, Nicholls, Samantha, Lansita, Janice, Kalra, Ashish
Publicado 2021

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015

por Dagbay, Kevin B., Treece, Erin, Streich, Frederick C., Jackson, Justin W., Faucette, Ryan R., Nikiforov, Anastasia, Lin, Susan C., Boston, Chris J., Nicholls, Samantha B., Capili, Allan D., Carven, Gregory J.
Publicado 2020

Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

por Beck, Alain, Nowak, Christine, Meshulam, Deborah, Reynolds, Kristina, Chen, David, Pacardo, Dennis B., Nicholls, Samantha B., Carven, Gregory J., Gu, Zhenyu, Fang, Jing, Wang, Dongdong, Katiyar, Amit, Xiang, Tao, Liu, Hongcheng
Publicado 2022

Experimental evidence for the age dependence of tau protein spread in the brain

por Wegmann, Susanne, Bennett, Rachel E., Delorme, Louis, Robbins, Ashley B., Hu, Miwei, McKenzie, Danny, Kirk, Molly J., Schiantarelli, Julia, Tunio, Nahel, Amaral, Ana C., Fan, Zhanyun, Nicholls, Samantha, Hudry, Eloise, Hyman, Bradley T.
Publicado 2019

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

por Nicholls, Samantha B., DeVos, Sarah L., Commins, Caitlin, Nobuhara, Chloe, Bennett, Rachel E., Corjuc, Diana L., Maury, Eduardo, Eftekharzadeh, Bahareh, Akingbade, Ololade, Fan, Zhanyun, Roe, Allyson D., Takeda, Shuko, Wegmann, Susanne, Hyman, Bradley T.
Publicado 2017

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

por Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T
Publicado 2015

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

por Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.
Publicado 2015