Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

por Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Publicado 2007

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

por Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Publicado 2014

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

por Vickers, Timothy A., Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Linsley, Peter S., Crooke, Stanley T.
Publicado 2009

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

por Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Publicado 2017

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado 2014