RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

por Liang, Xue-Hai, Sun, Hong, Nichols, Joshua G., Crooke, Stanley T.
Publicado 2017

Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

por Liang, Xue-Hai, Nichols, Joshua G, Sun, Hong, Crooke, Stanley T
Publicado 2018

Perinuclear positioning of endosomes can affect PS-ASO activities

por Liang, Xue-hai, Nichols, Joshua G, Tejera, Dario, Crooke, Stanley T
Publicado 2021

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

por Liang, Xue-hai, Nichols, Joshua G, De Hoyos, Cheryl L, Crooke, Stanley T
Publicado 2020

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

por Liang, Xue-hai, Nichols, Joshua G, Hsu, Chih-Wei, Vickers, Timothy A, Crooke, Stanley T
Publicado 2019

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

por Liang, Xue-Hai, Nichols, Joshua G, De Hoyos, Cheryl Li, Sun, Hong, Zhang, Lingdi, Crooke, Stanley T
Publicado 2021

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

por Liang, Xue-Hai, Shen, Wen, Sun, Hong, Kinberger, Garth A., Prakash, Thazha P., Nichols, Joshua G., Crooke, Stanley T.
Publicado 2016

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

por Liang, Xue-hai, Sun, Hong, Hsu, Chih-Wei, Nichols, Joshua G, Vickers, Timothy A, De Hoyos, Cheryl L, Crooke, Stanley T
Publicado 2020

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

por Liang, Xue-hai, Sun, Hong, Nichols, Joshua G, Allen, Nickolas, Wang, Shiyu, Vickers, Timothy A, Shen, Wen, Hsu, Chih-Wei, Crooke, Stanley T
Publicado 2018

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active...

por Zhang, Lingdi, Liang, Xue-hai, De Hoyos, Cheryl Li, Migawa, Michael, Nichols, Joshua G., Freestone, Graeme, Tian, Jun, Seth, Punit P., Crooke, Stanley T.
Publicado 2022

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

por Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Publicado 2019