Functional characterization of the vaccinia virus I5 protein

por Unger, Bethany, Nichols, R Jeremy, Stanitsa, Eleni S, Traktman, Paula
Publicado 2008

Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism

por Chittoor-Vinod, Vinita G., Nichols, R. Jeremy, Schüle, Birgitt
Publicado 2021

Editorial: LRRK2—Fifteen Years From Cloning to the Clinic

por Rideout, Hardy, Greggio, Elisa, Kortholt, Arjan, Nichols, R. Jeremy
Publicado 2022

Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk

por Lesniak, Robert K., Nichols, R. Jeremy, Montine, Thomas J.
Publicado 2022

LRRK2 dephosphorylation increases its ubiquitination

por Zhao, Jing, Molitor, Tyler P., Langston, J. William, Nichols, R. Jeremy
Publicado 2015

LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status

por Reynolds, April, Doggett, Elizabeth A., Riddle, Steve M., Lebakken, Connie S., Nichols, R. Jeremy
Publicado 2014

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

por Dzamko, Nicolas, Deak, Maria, Hentati, Faycal, Reith, Alastair D., Prescott, Alan R., Alessi, Dario R., Nichols, R. Jeremy
Publicado 2010

Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation

por Hermanson, Spencer B., Carlson, Coby B., Riddle, Steven M., Zhao, Jing, Vogel, Kurt W., Nichols, R. Jeremy, Bi, Kun
Publicado 2012

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

por Nichols, R. Jeremy, Dzamko, Nicolas, Morrice, Nicholas A., Campbell, David G., Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R., Alessi, Dario R.
Publicado 2010

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

por Marchand, Antoine, Sarchione, Alessia, Athanasopoulos, Panagiotis S., Roy, Hélène Bauderlique-Le, Goveas, Liesel, Magnez, Romain, Drouyer, Matthieu, Emanuele, Marco, Ho, Franz Y., Liberelle, Maxime, Melnyk, Patricia, Lebègue, Nicolas, Thuru, Xavier, Nichols, R. Jeremy, Greggio, Elisa, Kortholt, Arjan, Galli, Thierry, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc
Publicado 2022

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

por Fernández, Belén, Chittoor-Vinod, Vinita G., Kluss, Jillian H., Kelly, Kaela, Bryant, Nicole, Nguyen, An Phu Tran, Bukhari, Syed A., Smith, Nathan, Lara Ordóñez, Antonio Jesús, Fdez, Elena, Chartier-Harlin, Marie-Christine, Montine, Thomas J., Wilson, Mark A., Moore, Darren J., West, Andrew B., Cookson, Mark R., Nichols, R. Jeremy, Hilfiker, Sabine
Publicado 2022

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

por Stormo, Adrienne E.D., Shavarebi, Farbod, FitzGibbon, Molly, Earley, Elizabeth M., Ahrendt, Hannah, Lum, Lotus S., Verschueren, Erik, Swaney, Danielle L., Skibinski, Gaia, Ravisankar, Abinaya, van Haren, Jeffrey, Davis, Emily J., Johnson, Jeffrey R., Von Dollen, John, Balen, Carson, Porath, Jacob, Crosio, Claudia, Mirescu, Christian, Iaccarino, Ciro, Dauer, William T., Nichols, R. Jeremy, Wittmann, Torsten, Cox, Timothy C., Finkbeiner, Steve, Krogan, Nevan J., Oakes, Scott A., Hiniker, Annie
Publicado 2022