Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test – Demonstrated in vitro and ex vivo

por Madsen, Daniel Elenius, Nichols, Timothy C., Merricks, Elizabeth P., Waters, Emily K., Wiinberg, Bo
Publicado 2017

Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa

por Nichols, Timothy C., Levy, Howard, Merricks, Elizabeth P., Raymer, Robin A., Lee, Martin L.
Publicado 2020

Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

por Sun, Junjiang, Chen, Xiaojing, Chai, Zheng, Niu, Hongqian, Dobbins, Amanda L., Nichols, Timothy C., Li, Chengwen
Publicado 2022

Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog

por Shao, Wenwei, Sun, Junjiang, Chen, Xiaojing, Dobbins, Amanda, Merricks, Elizabeth P., Samulski, R. Jude, Nichols, Timothy C., Li, Chengwen
Publicado 2022

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

por Markusic, David M., Nichols, Timothy C., Merricks, Elizabeth P., Palaschak, Brett, Zolotukhin, Irene, Marsic, Damien, Zolotukhin, Sergei, Srivastava, Arun, Herzog, Roland W.
Publicado 2017

Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4‐driven transcriptional state

por Yan, Wen, Chung, Chi‐Yeh, Xie, Tao, Ozeck, Mark, Nichols, Timothy C., Frey, Jessica, Udyavar, Akshata R., Sharma, Shikhar, Paul, Thomas A.
Publicado 2021

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies

por Nichols, Timothy C., Bellinger, Dwight A., Merricks, Elizabeth P., Raymer, Robin A., Kloos, Mark T., DeFriess, Natalie, Ragni, Margaret V., Griggs, Thomas R.
Publicado 2010

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs

por Davis, Bryan T., Wang, Xiao-Jun, Rohret, Judy A., Struzynski, Jason T., Merricks, Elizabeth P., Bellinger, Dwight A., Rohret, Frank A., Nichols, Timothy C., Rogers, Christopher S.
Publicado 2014

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet

por Nichols, Timothy C., Merricks, Elizabeth P., Bellinger, Dwight A., Raymer, Robin A., Yu, Jing, Lam, Diana, Koch, Gary G., Busby, Walker H., Clemmons, David R.
Publicado 2015

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

por Herzog, Roland W., Nichols, Timothy C., Su, Jin, Zhang, Bei, Sherman, Alexandra, Merricks, Elizabeth P., Raymer, Robin, Perrin, George Q., Häger, Mattias, Wiinberg, Bo, Daniell, Henry
Publicado 2017

Superior human hepatocyte transduction with Adeno-associated Virus Vector Serotype 7

por Shao, Wenwei, Pei, Xiaolei, Cui, Caibin, Askew, Charles, Dobbins, Amanda, Chen, Xiaojing, Abajas, Yasmina L., Gerber, David A., Samulski, R. Jude, Nichols, Timothy C., Li, Chengwen
Publicado 2019

Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release

por Taylor, James B., Malone-Povolny, Maggie J., Merricks, Elizabeth P., Wimsey, Lauren E., Soliman, Daniel, Nichols, Timothy C., Wallet, Shannon M., Maile, Robert, Schoenfisch, Mark H.
Publicado 2022

Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging

por O’Brien, Peter J, Lee, Michelle, Spilker, Mary E, Zhang, Cathy C, Yan, Zhengming, Nichols, Timothy C, Li, Wenlin, Johnson, Caroline H, Patti, Gary J, Siuzdak, Gary
Publicado 2013

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs

por Sun, Junjiang, Shao, Wenwei, Chen, Xiaojing, Merricks, Elizabeth P., Wimsey, Lauren, Abajas, Yasmina L., Niemeyer, Glenn P., Lothrop, Clinton D., Monahan, Paul E., Samulski, R. Jude, Nichols, Timothy C., Li, Chengwen
Publicado 2018

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

por Pei, Xiaolei, Shao, Wenwei, Xing, Allene, Askew, Charles, Chen, Xiaojing, Cui, Caibin, Abajas, Yasmina L., Gerber, David A., Merricks, Elizabeth P., Nichols, Timothy C., Li, Wuping, Samulski, R. Jude, Li, Chengwen
Publicado 2020

Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

por Haurigot, Virginia, Mingozzi, Federico, Buchlis, George, Hui, Daniel J, Chen, Yifeng, Basner-Tschakarjan, Etiena, Arruda, Valder R, Radu, Antoneta, Franck, Helen G, Wright, J Fraser, Zhou, Shangzhen, Stedman, Hansell H, Bellinger, Dwight A, Nichols, Timothy C, High, Katherine A
Publicado 2010

A long-term study of AAV gene therapy in hemophilia A dogs identifies clonal expansions of transduced liver cells

por Nguyen, Giang N., Everett, John K., Kafle, Samita, Roche, Aoife M., Raymond, Hayley E., Leiby, Jacob, Wood, Christian, Assenmacher, Charles-Antoine, Merricks, Elizabeth P., Long, C. Tyler, Kazazian, Haig H., Nichols, Timothy C., Bushman, Frederic D., Sabatino, Denise E.
Publicado 2020

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

por Du, Lily M., Nurden, Paquita, Nurden, Alan T., Nichols, Timothy C., Bellinger, Dwight A., Jensen, Eric S., Haberichter, Sandra L., Merricks, Elizabeth, Raymer, Robin A., Fang, Juan, Koukouritaki, Sevasti B., Jacobi, Paula M., Hawkins, Troy B., Cornetta, Kenneth, Shi, Qizhen, Wilcox, David A.
Publicado 2013

Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

por Barsotti, Anthony M., Ryskin, Michael, Zhong, Wenyan, Zhang, Wei-Guo, Giannakou, Andreas, Loreth, Christine, Diesl, Veronica, Follettie, Maximillian, Golas, Jonathan, Lee, Michelle, Nichols, Timothy, Fan, Conglin, Li, Gang, Dann, Stephen, Fantin, Valeria R., Arndt, Kim, Verhelle, Dominique, Rollins, Robert A.
Publicado 2015

Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk

por Mátrai, Janka, Cantore, Alessio, Bartholomae, Cynthia C, Annoni, Andrea, Wang, Wei, Acosta-Sanchez, Abel, Samara-Kuko, Ermira, De Waele, Liesbeth, Ma, Ling, Genovese, Pietro, Damo, Martina, Arens, Anne, Goudy, Kevin, Nichols, Timothy C, von Kalle, Christof, Chuah, Marinee K L, Roncarolo, Maria Grazia, Schmidt, Manfred, VandenDriessche, Thierry, Naldini, Luigi
Publicado 2011