Assaying DNA double-strand break induction and repair as fast as a speeding comet

por Nickoloff, Jac A.
Publicado 2013

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy

por Nickoloff, Jac A.
Publicado 2022

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

por Nickoloff, Jac A., Sharma, Neelam, Taylor, Lynn
Publicado 2020

Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats

por Schildkraut, Ezra, Miller, Cheryl A., Nickoloff, Jac A.
Publicado 2005

Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy

por Nickoloff, Jac A., Taylor, Lynn, Sharma, Neelam, Kato, Takamitsu A.
Publicado 2021

BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage

por Lu, Huimei, Yue, Jingyin, Meng, Xiangbing, Nickoloff, Jac A., Shen, Zhiyuan
Publicado 2007

The Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination

por Nickoloff, Jac A., Sharma, Neelam, Taylor, Lynn, Allen, Sage J., Hromas, Robert
Publicado 2021

Nucleases and Co-Factors in DNA Replication Stress Responses

por Nickoloff, Jac A., Sharma, Neelam, Taylor, Lynn, Allen, Sage J., Hromas, Robert
Publicado 2022

Drugging the Cancers Addicted to DNA Repair

por Nickoloff, Jac A., Jones, Dennie, Lee, Suk-Hee, Williamson, Elizabeth A., Hromas, Robert
Publicado 2017

Metnase and EEPD1: DNA Repair Functions and Potential Targets in Cancer Therapy

por Nickoloff, Jac A., Sharma, Neelam, Taylor, Lynn, Allen, Sage J., Lee, Suk-Hee, Hromas, Robert
Publicado 2022

The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart

por Kim, Hyun-Suk, Chen, Qiujia, Kim, Sung-Kyung, Nickoloff, Jac A., Hromas, Robert, Georgiadis, Millie M., Lee, Suk-Hee
Publicado 2014

The DNA repair component Metnase regulates Chk1 stability

por Williamson, Elizabeth A, Wu, Yuehan, Singh, Sudha, Byrne, Michael, Wray, Justin, Lee, Suk-Hee, Nickoloff, Jac A, Hromas, Robert
Publicado 2014

Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells

por Wray, Justin, Williamson, Elizabeth A., Royce, Melanie, Shaheen, Montaser, Beck, Brian D., Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Publicado 2009

Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses

por Sharma, Neelam, Speed, Michael C, Allen, Christopher P, Maranon, David G, Williamson, Elizabeth, Singh, Sudha, Hromas, Robert, Nickoloff, Jac A
Publicado 2020

The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis

por Chun, Changzoon, Wu, Yuehan, Lee, Suk-Hee, Williamson, Elizabeth A., Reinert, Brian L., Jaiswal, Aruna Shanker, Nickoloff, Jac A., Hromas, Robert A.
Publicado 2016

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

por Liu, Shengqin, Opiyo, Stephen O., Manthey, Karoline, Glanzer, Jason G., Ashley, Amanda K., Amerin, Courtney, Troksa, Kyle, Shrivastav, Meena, Nickoloff, Jac A., Oakley, Greg G.
Publicado 2012

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

por Hromas, Robert, Kim, Hyun-Suk, Sidhu, Gurjit, Williamson, Elizabeth, Jaiswal, Aruna, Totterdale, Taylor A., Nole, Jocelyn, Lee, Suk-Hee, Nickoloff, Jac A., Kong, Kimi Y.
Publicado 2017

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

por Williamson, Elizabeth A., Rasila, Kanwaldeep Kaur, Corwin, Lori Kwan, Wray, Justin, Beck, Brian D., Severns, Virginia, Mobarak, Charlotte, Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Publicado 2008

Metnase promotes restart and repair of stalled and collapsed replication forks

por De Haro, Leyma P., Wray, Justin, Williamson, Elizabeth A., Durant, Stephen T., Corwin, Lori, Gentry, Amanda C., Osheroff, Neil, Lee, Suk-Hee, Hromas, Robert, Nickoloff, Jac A.
Publicado 2010

DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E(2) Growth Factor Release in Response to Low and High LET Ionizing Radiation

por Allen, Christopher P., Tinganelli, Walter, Sharma, Neelam, Nie, Jingyi, Sicard, Cory, Natale, Francesco, King, Maurice, Keysar, Steven B., Jimeno, Antonio, Furusawa, Yoshiya, Okayasu, Ryuichi, Fujimori, Akira, Durante, Marco, Nickoloff, Jac A.
Publicado 2015