Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability

por Dhoonmoon, Ashna, Nicolae, Claudia M
Publicado 2023

The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1

por Dhoonmoon, Ashna, Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases

por Hale, Anastasia, Dhoonmoon, Ashna, Straka, Joshua, Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2023

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

por Dhoonmoon, Ashna, Schleicher, Emily M, Clements, Kristen E, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2020

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

por Schleicher, Emily M, Galvan, Adri M, Imamura-Kawasawa, Yuka, Moldovan, George-Lucian, Nicolae, Claudia M
Publicado 2018

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

por Thakar, Tanay, Dhoonmoon, Ashna, Straka, Joshua, Schleicher, Emily M., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

por Clements, Kristen E, Thakar, Tanay, Nicolae, Claudia M, Liang, Xinwen, Wang, Hong-Gang, Moldovan, George-Lucian
Publicado 2018

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Khatib, Jude B., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival

por Khatib, Jude B., Schleicher, Emily M., Jackson, Lindsey M., Dhoonmoon, Ashna, Moldovan, George-Lucian, Nicolae, Claudia M.
Publicado 2022

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

por Thakar, Tanay, Leung, Wendy, Nicolae, Claudia M., Clements, Kristen E., Shen, Binghui, Bielinsky, Anja-Katrin, Moldovan, George-Lucian
Publicado 2020

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells

por Jackson, Lindsey M, Dhoonmoon, Ashna, Hale, Anastasia, Dennis, Kady A, Schleicher, Emily M, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2021

Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4

por Uckelmann, Hannah, Blaszkiewicz, Sandra, Nicolae, Claudia, Haas, Simon, Schnell, Alexandra, Wurzer, Stephan, Wagener, Raimund, Aszodi, Attila, Essers, Marieke Alida Gertruda
Publicado 2016

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2020

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

por Nicolae, Claudia M., Aho, Erin R., Choe, Katherine N., Constantin, Daniel, Hu, He-Juan, Lee, Deokjae, Myung, Kyungjae, Moldovan, George-Lucian
Publicado 2015

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

por Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Publicado 2021

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

por Li, Ping, Fleischhauer, Lutz, Nicolae, Claudia, Prein, Carina, Farkas, Zsuzsanna, Saller, Maximilian Michael, Prall, Wolf Christian, Wagener, Raimund, Heilig, Juliane, Niehoff, Anja, Clausen-Schaumann, Hauke, Alberton, Paolo, Aszodi, Attila
Publicado 2020

The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1

por Hirschler-Laszkiewicz, Iwona, Festa, Fernanda, Huang, Suming, Moldovan, George-Lucian, Nicolae, Claudia, Dhoonmoon, Ashna, Bao, Lei, Keefer, Kerry, Chen, Shu-jen, Wang, Hong-Gang, Cheung, Joseph Y., Miller, Barbara A.
Publicado 2022

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

por Clements, Kristen E., Schleicher, Emily M., Thakar, Tanay, Hale, Anastasia, Dhoonmoon, Ashna, Tolman, Nathanial J., Sharma, Anchal, Liang, Xinwen, Imamura Kawasawa, Yuka, Nicolae, Claudia M., Wang, Hong-Gang, De, Subhajyoti, Moldovan, George-Lucian
Publicado 2020

A higher‐level classification of the Pannonian and western Pontic steppe grasslands (Central and Eastern Europe)

por Willner, Wolfgang, Kuzemko, Anna, Dengler, Jürgen, Chytrý, Milan, Bauer, Norbert, Becker, Thomas, Biţă‐Nicolae, Claudia, Botta‐Dukát, Zoltán, Čarni, Andraž, Csiky, János, Igić, Ruzica, Kącki, Zygmunt, Korotchenko, Iryna, Kropf, Matthias, Krstivojević‐Ćuk, Mirjana, Krstonošić, Daniel, Rédei, Tamás, Ruprecht, Eszter, Schratt‐Ehrendorfer, Luise, Semenishchenkov, Yuri, Stančić, Zvjezdana, Vashenyak, Yulia, Vynokurov, Denys, Janišová, Monika
Publicado 2016

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1

por Abu-Libdeh, Bassam, Jhujh, Satpal S., Dhar, Srijita, Sommers, Joshua A., Datta, Arindam, Longo, Gabriel M.C., Grange, Laura J., Reynolds, John J., Cooke, Sophie L., McNee, Gavin S., Hollingworth, Robert, Woodward, Beth L., Ganesh, Anil N., Smerdon, Stephen J., Nicolae, Claudia M., Durlacher-Betzer, Karina, Molho-Pessach, Vered, Abu-Libdeh, Abdulsalam, Meiner, Vardiella, Moldovan, George-Lucian, Roukos, Vassilis, Harel, Tamar, Brosh, Robert M., Stewart, Grant S.
Publicado 2022