In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity

por Mohammad, Thahani S. Habeeb, Gupta, Yash, Reidl, Cory T., Nicolaescu, Vlad, Gula, Haley, Durvasula, Ravi, Kempaiah, Prakasha, Becker, Daniel P.
Publicado 2023

Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

por Asiedu, Seth Osei, Gupta, Yash, Nicolaescu, Vlad, Gula, Haley, Caulfield, Thomas R., Durvasula, Ravi, Kempaiah, Prakasha, Kwofie, Samuel K., Wilson, Michael D.
Publicado 2023

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

por Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej
Publicado 2021

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release

por Xiao, Fei, Wang, Stanley, Barouch-Bentov, Rina, Neveu, Gregory, Pu, Szuyuan, Beer, Melanie, Schor, Stanford, Kumar, Sathish, Nicolaescu, Vlad, Lindenbach, Brett D., Randall, Glenn, Einav, Shirit
Publicado 2018

Spherical nucleic acids as an infectious disease vaccine platform

por Teplensky, Michelle H., Distler, Max E., Kusmierz, Caroline D., Evangelopoulos, Michael, Gula, Haley, Elli, Derek, Tomatsidou, Anastasia, Nicolaescu, Vlad, Gelarden, Ian, Yeldandi, Anjana, Batlle, Daniel, Missiakas, Dominique, Mirkin, Chad A.
Publicado 2022

The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection

por Schor, Stanford, Pu, Szuyuan, Nicolaescu, Vlad, Azari, Siavash, Kõivomägi, Mardo, Karim, Marwah, Cassonnet, Patricia, Saul, Sirle, Neveu, Gregory, Yueh, Andrew, Demeret, Caroline, Skotheim, Jan M., Jacob, Yves, Randall, Glenn, Einav, Shirit
Publicado 2022

Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection

por Hassler, Luise, Wysocki, Jan, Ahrendsen, Jared T, Ye, Minghao, Gelarden, Ian, Nicolaescu, Vlad, Tomatsidou, Anastasia, Gula, Haley, Cianfarini, Cosimo, Forster, Peter, Khurram, Nigar, Singer, Benjamin D, Randall, Glenn, Missiakas, Dominique, Henkin, Jack, Batlle, Daniel
Publicado 2023

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19

por Zhou, Yadi, Liu, Yuan, Gupta, Shagun, Paramo, Mauricio I., Hou, Yuan, Mao, Chengsheng, Luo, Yuan, Judd, Julius, Wierbowski, Shayne, Bertolotti, Marta, Nerkar, Mriganka, Jehi, Lara, Drayman, Nir, Nicolaescu, Vlad, Gula, Haley, Tay, Savaş, Randall, Glenn, Lis, John T., Feschotte, Cédric, Erzurum, Serpil C., Cheng, Feixiong, Yu, Haiyuan
Publicado 2022

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

por Osipiuk, Jerzy, Azizi, Saara-Anne, Dvorkin, Steve, Endres, Michael, Jedrzejczak, Robert, Jones, Krysten A., Kang, Soowon, Kathayat, Rahul S., Kim, Youngchang, Lisnyak, Vladislav G., Maki, Samantha L., Nicolaescu, Vlad, Taylor, Cooper A., Tesar, Christine, Zhang, Yu-An, Zhou, Zhiyao, Randall, Glenn, Michalska, Karolina, Snyder, Scott A., Dickinson, Bryan C., Joachimiak, Andrzej
Publicado 2021

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

por Nguyen, Long Chi, Yang, Dongbo, Nicolaescu, Vlad, Best, Thomas J., Ohtsuki, Takashi, Chen, Shao-Nong, Friesen, J. Brent, Drayman, Nir, Mohamed, Adil, Dann, Christopher, Silva, Diane, Gula, Haley, Jones, Krysten A., Millis, J. Michael, Dickinson, Bryan C., Tay, Savaş, Oakes, Scott A., Pauli, Guido F., Meltzer, David O., Randall, Glenn, Rosner, Marsha Rich
Publicado 2021

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

por Nguyen, Long C., Renner, David M., Silva, Diane, Yang, Dongbo, Parenti, Nicholas, Medina, Kaeri M., Nicolaescu, Vlad, Gula, Haley, Drayman, Nir, Valdespino, Andrea, Mohamed, Adil, Dann, Christopher, Wannemo, Kristin, Robinson-Mailman, Lydia, Gonzalez, Alan, Stock, Letícia, Cao, Mengrui, Qiao, Zeyu, Moellering, Raymond E., Tay, Savas, Randall, Glenn, Beers, Michael F., Rosner, Marsha Rich, Oakes, Scott A., Weiss, Susan R.
Publicado 2022

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

por Nguyen, Long C., Renner, David M., Silva, Diane, Yang, Dongbo, Parenti, Nicholas A., Medina, Kaeri M., Nicolaescu, Vlad, Gula, Haley, Drayman, Nir, Valdespino, Andrea, Mohamed, Adil, Dann, Christopher, Wannemo, Kristin, Robinson-Mailman, Lydia, Gonzalez, Alan, Stock, Letícia, Cao, Mengrui, Qiao, Zeyu, Moellering, Raymond E., Tay, Savas, Randall, Glenn, Beers, Michael F., Rosner, Marsha Rich, Oakes, Scott A., Weiss, Susan R.
Publicado 2022

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

por Gray, Laura T., Raczy, Michal M., Briquez, Priscilla S., Marchell, Tiffany M., Alpar, Aaron T., Wallace, Rachel P., Volpatti, Lisa R., Sasso, Maria Stella, Cao, Shijie, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Watkins, Elyse A., Solanki, Ani, Mitrousis, Nikolaos, Reda, Joseph W., Yu, Shann S., Tremain, Andrew C., Wang, Ruyi, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Manicassamy, Balaji, Randall, Glenn, Wilson, D. Scott, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.
Publicado 2021

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

por Volpatti, Lisa R., Wallace, Rachel P., Cao, Shijie, Raczy, Michal M., Wang, Ruyi, Gray, Laura T., Alpar, Aaron T., Briquez, Priscilla S., Mitrousis, Nikolaos, Marchell, Tiffany M., Sasso, Maria Stella, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Solanki, Ani, Watkins, Elyse A., Schnorenberg, Mathew R., Tremain, Andrew C., Reda, Joseph W., Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Yu, Shann S., Manicassamy, Balaji, LaBelle, James L., Tirrell, Matthew V., Randall, Glenn, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.
Publicado 2021

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

por Volpatti, Lisa R., Wallace, Rachel P., Cao, Shijie, Raczy, Michal M., Wang, Ruyi, Gray, Laura T., Alpar, Aaron T., Briquez, Priscilla S., Mitrousis, Nikolaos, Marchell, Tiffany M., Sasso, Maria Stella, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Solanki, Ani, Watkins, Elyse A., Schnorenberg, Mathew R., Tremain, Andrew C., Reda, Joseph W., Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Yu, Shann S., Manicassamy, Balaji, LaBelle, James L., Tirrell, Matthew V., Randall, Glenn, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.
Publicado 2021

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

por Lian, Qizhou, Zhang, Kui, Zhang, Zhao, Duan, Fuyu, Guo, Liyan, Luo, Weiren, Mok, Bobo Wing-Yee, Thakur, Abhimanyu, Ke, Xiaoshan, Motallebnejad, Pedram, Nicolaescu, Vlad, Chen, Jonathan, Ma, Chui Yan, Zhou, Xiaoya, Han, Shuo, Han, Teng, Zhang, Wei, Tan, Adrian Y., Zhang, Tuo, Wang, Xing, Xu, Dong, Xiang, Jenny, Xu, Aimin, Liao, Can, Huang, Fang-Ping, Chen, Ya-Wen, Na, Jie, Randall, Glenn, Tse, Hung-fat, Chen, Zhiwei, Chen, Yin, Chen, Huanhuan Joyce
Publicado 2022

Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

por El-Shennawy, Lamiaa, Hoffmann, Andrew D., Dashzeveg, Nurmaa Khund, McAndrews, Kathleen M., Mehl, Paul J., Cornish, Daphne, Yu, Zihao, Tokars, Valerie L., Nicolaescu, Vlad, Tomatsidou, Anastasia, Mao, Chengsheng, Felicelli, Christopher J., Tsai, Chia-Feng, Ostiguin, Carolina, Jia, Yuzhi, Li, Lin, Furlong, Kevin, Wysocki, Jan, Luo, Xin, Ruivo, Carolina F., Batlle, Daniel, Hope, Thomas J., Shen, Yang, Chae, Young Kwang, Zhang, Hui, LeBleu, Valerie S., Shi, Tujin, Swaminathan, Suchitra, Luo, Yuan, Missiakas, Dominique, Randall, Glenn C., Demonbreun, Alexis R., Ison, Michael G., Kalluri, Raghu, Fang, Deyu, Liu, Huiping
Publicado 2022

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

por Drayman, Nir, DeMarco, Jennifer K., Jones, Krysten A., Azizi, Saara-Anne, Froggatt, Heather M., Tan, Kemin, Maltseva, Natalia Ivanovna, Chen, Siquan, Nicolaescu, Vlad, Dvorkin, Steve, Furlong, Kevin, Kathayat, Rahul S., Firpo, Mason R., Mastrodomenico, Vincent, Bruce, Emily A., Schmidt, Madaline M., Jedrzejczak, Robert, Muñoz-Alía, Miguel Á., Schuster, Brooke, Nair, Vishnu, Han, Kyu-yeon, O’Brien, Amornrat, Tomatsidou, Anastasia, Meyer, Bjoern, Vignuzzi, Marco, Missiakas, Dominique, Botten, Jason W., Brooke, Christopher B., Lee, Hyun, Baker, Susan C., Mounce, Bryan C., Heaton, Nicholas S., Severson, William E., Palmer, Kenneth E., Dickinson, Bryan C., Joachimiak, Andrzej, Randall, Glenn, Tay, Savaş
Publicado 2021