Improved SARS-CoV-2 M(pro) inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

por Vuong, Wayne, Fischer, Conrad, Khan, Muhammad Bashir, van Belkum, Marco J., Lamer, Tess, Willoughby, Kurtis D., Lu, Jimmy, Arutyunova, Elena, Joyce, Michael A., Saffran, Holly A., Shields, Justin A., Young, Howard S., Nieman, James A., Tyrrell, D. Lorne, Lemieux, M. Joanne, Vederas, John C.
Publicado 2021

SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

por Chen, Sizhu Amelia, Arutyunova, Elena, Lu, Jimmy, Khan, Muhammad Bashir, Rut, Wioletta, Zmudzinski, Mikolaj, Shahbaz, Shima, Iyyathurai, Jegan, Moussa, Eman W., Turner, Zoe, Bai, Bing, Lamer, Tess, Nieman, James A., Vederas, John C., Julien, Olivier, Drag, Marcin, Elahi, Shokrollah, Young, Howard S., Lemieux, M. Joanne
Publicado 2023

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

por Blair, Wade S., Pickford, Chris, Irving, Stephen L., Brown, David G., Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, Jackson, Lynn, Hunt, Rachael, Kjerrstrom, Anne, Nieman, James A., Patick, Amy K., Perros, Manos, Scott, Andrew D., Whitby, Kevin, Wu, Hua, Butler, Scott L.
Publicado 2010

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

por Ganesan, Aravindhan, Ahmed, Marawan, Okoye, Isobel, Arutyunova, Elena, Babu, Dinesh, Turnbull, William L., Kundu, Joydeb Kumar, Shields, Justin, Agopsowicz, Katharine Cheryl, Xu, Lai, Tabana, Yasser, Srivastava, Nutan, Zhang, Guangzhi, Moon, Tae Chul, Belovodskiy, Alexandr, Hena, Mostofa, Kandadai, Appan Srinivas, Hosseini, Seyedeh Nargess, Hitt, Mary, Walker, John, Smylie, Michael, West, Frederick G., Siraki, Arno G., Lemieux, M. Joanne, Elahi, Shokrollah, Nieman, James A., Tyrrell, D. Lorne, Houghton, Michael, Barakat, Khaled
Publicado 2019