Uremic Toxins in Organ Crosstalk

por Lowenstein, Jerome, Nigam, Sanjay K.
Publicado 2021

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions

por Jamshidi, Neema, Nigam, Sanjay K.
Publicado 2022

Organic Anion Transporters (OAT) and Other SLC22 Transporters in Progression of Renal Cell Carcinoma

por Whisenant, Thomas C., Nigam, Sanjay K.
Publicado 2022

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

por Wu, Wei, Bush, Kevin T., Nigam, Sanjay K.
Publicado 2017

Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice

por Jamshidi, Neema, Nigam, Kabir B., Nigam, Sanjay K.
Publicado 2023

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis

por Rosenthal, Sara Brin, Bush, Kevin T., Nigam, Sanjay K.
Publicado 2019

Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2

por He, Xiao, Garza, Denisse, Nigam, Sanjay K., Chang, Geoffrey
Publicado 2016

What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis

por Vanholder, Raymond, Nigam, Sanjay K., Burtey, Stéphane, Glorieux, Griet
Publicado 2022

Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways

por Eraly, Satish A., Liu, Henry C., Jamshidi, Neema, Nigam, Sanjay K.
Publicado 2015

Organic Anion and Cation SLC22 “Drug” Transporter (Oat1, Oat3, and Oct1) Regulation during Development and Maturation of the Kidney Proximal Tubule

por Gallegos, Thomas F., Martovetsky, Gleb, Kouznetsova, Valentina, Bush, Kevin T., Nigam, Sanjay K.
Publicado 2012

The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

por Nigam, Sanjay K., Bush, Kevin T., Bhatnagar, Vibha, Poloyac, Samuel M., Momper, Jeremiah D.
Publicado 2020

A key role for the transporter OAT1 in systemic lipid metabolism

por Granados, Jeffry C., Nigam, Anisha K., Bush, Kevin T., Jamshidi, Neema, Nigam, Sanjay K.
Publicado 2021

SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo

por Zhang, Patrick, Azad, Priti, Engelhart, Darcy C., Haddad, Gabriel G., Nigam, Sanjay K.
Publicado 2021

The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

por Granados, Jeffry C., Ermakov, Vladimir, Maity, Koustav, Vera, David R., Chang, Geoffrey, Nigam, Sanjay K.
Publicado 2023

GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling

por Tee, James B., Choi, Yohan, Dnyanmote, Ankur, Decambre, Marvalyn, Ito, Chiharu, Bush, Kevin T., Nigam, Sanjay K.
Publicado 2013

Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress

por Engelhart, Darcy C., Azad, Priti, Ali, Suwayda, Granados, Jeffry C., Haddad, Gabriel G., Nigam, Sanjay K.
Publicado 2020

Regulation of Human Endogenous Metabolites by Drug Transporters and Drug Metabolizing Enzymes: An Analysis of Targeted SNP-Metabolite Associations

por Granados, Jeffry C., Watrous, Jeramie D., Long, Tao, Rosenthal, Sara Brin, Cheng, Susan, Jain, Mohit, Nigam, Sanjay K.
Publicado 2023

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells

por Kumar, Nathan, Richter, Jenna, Cutts, Josh, Bush, Kevin T, Trujillo, Cleber, Nigam, Sanjay K, Gaasterland, Terry, Brafman, David, Willert, Karl
Publicado 2015

Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs

por Engelhart, Darcy C., Granados, Jeffry C., Shi, Da, Saier, Milton H., Baker, Michael E., Abagyan, Ruben, Nigam, Sanjay K.
Publicado 2020

Loss of the Heparan Sulfate Sulfotransferase, Ndst1, in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice

por Crawford, Brett E., Garner, Omai B., Bishop, Joseph R., Zhang, David Y., Bush, Kevin T., Nigam, Sanjay K., Esko, Jeffrey D.
Publicado 2010