A novel hybrid ultrafast shape descriptor method for use in virtual screening

por Cannon, Edward O, Nigsch, Florian, Mitchell, John BO
Publicado 2008

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction

por O'Boyle, Noel M, Palmer, David S, Nigsch, Florian, Mitchell, John BO
Publicado 2008

Predicting the mechanism of phospholipidosis

por Lowe, Robert, Mussa, Hamse Y, Nigsch, Florian, Glen, Robert C, Mitchell, John BO
Publicado 2012

Determination of minimal transcriptional signatures of compounds for target prediction

por Nigsch, Florian, Hutz, Janna, Cornett, Ben, Selinger, Douglas W, McAllister, Gregory, Bandyopadhyay, Somnath, Loureiro, Joseph, Jenkins, Jeremy L
Publicado 2012

Genome-wide CRISPR-Cas9 screens identify mechanisms of BET bromodomain inhibitor sensitivity

por Estoppey, David, Schutzius, Gabi, Kolter, Christian, Salathe, Adrian, Wunderlin, Tiffany, Meyer, Amandine, Nigsch, Florian, Bouwmeester, Tewis, Hoepfner, Dominic, Kirkland, Susan
Publicado 2021

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

por Wegmann, Rebekka, Neri, Marilisa, Schuierer, Sven, Bilican, Bilada, Hartkopf, Huyen, Nigsch, Florian, Mapa, Felipa, Waldt, Annick, Cuttat, Rachel, Salick, Max R., Raymond, Joe, Kaykas, Ajamete, Roma, Guglielmo, Keller, Caroline Gubser
Publicado 2019

Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

por Gapp, Berangere, Jourdain, Marie, Bringer, Pauline, Kueng, Benjamin, Weber, Delphine, Osmont, Arnaud, Zurbruegg, Stefan, Knehr, Judith, Falchetto, Rocco, Roma, Guglielmo, Dietrich, William, Valdez, Reginald, Beckmann, Nicolau, Nigsch, Florian, Sanyal, Arun J., Ksiazek, Iwona
Publicado 2019

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

por Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John S., Phadke, Tanushree, Gambert, Romain, Keller, Caroline Gubser, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Frederiksen, Mathias, Schübeler, Dirk, Seuwen, Klaus, Bouwmeester, Tewis, Fodor, Barna D.
Publicado 2017

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

por Wang, Zhong-Yi, Keogh, Adrian, Waldt, Annick, Cuttat, Rachel, Neri, Marilisa, Zhu, Shanshan, Schuierer, Sven, Ruchti, Alexandra, Crochemore, Christophe, Knehr, Judith, Bastien, Julie, Ksiazek, Iwona, Sánchez-Taltavull, Daniel, Ge, Hui, Wu, Jing, Roma, Guglielmo, Helliwell, Stephen B., Stroka, Deborah, Nigsch, Florian
Publicado 2021

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

por Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia, Maher, Rob, Russ, Carsten, McAllister, Gregory, Reece-Hoyes, John S., Hoffman, Gregory R., Roma, Guglielmo, Müller, Matthias, Sailer, Andreas W., Helliwell, Stephen B.
Publicado 2018

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

por Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Gupta, Devendra Kumar, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Zeeman, Anne-Marie, Lee, Boon Heng, Hofman, Sam O, Faber, Bart W, Knehr, Judith, Pasini, Erica, Kinzel, Bernd, Bifani, Pablo, Bonamy, Ghislain M C, Bouwmeester, Tewis, Kocken, Clemens H M, Diagana, Thierry Tidiane
Publicado 2017

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

por Bertschi, Nicole L, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Knehr, Judith, Gupta, Devendra K, Hofman, Sam O, van der Werff, Nicole, Nieuwenhuis, Ivonne, Klooster, Els, Faber, Bart W, Flannery, Erika L, Mikolajczak, Sebastian A, Chuenchob, Vorada, Shrestha, Binesh, Beibel, Martin, Bouwmeester, Tewis, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Diagana, Thierry T, Kocken, Clemens HM, Roma, Guglielmo
Publicado 2018

IRF2 is a master regulator of human keratinocyte stem cell fate

por Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Alford, John, Russ, Carsten, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Beck, Tanner C., Jagannathan, Sajjeev, Olson, Calla M., Sheppard, Hadley E., Elsarrag, Selma Z., Bouwmeester, Tewis, Frederiksen, Mathias, Lohmann, Felix, Lin, Charles Y., Kirkland, Susan
Publicado 2019

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

por Sushko, Iurii, Novotarskyi, Sergii, Körner, Robert, Pandey, Anil Kumar, Rupp, Matthias, Teetz, Wolfram, Brandmaier, Stefan, Abdelaziz, Ahmed, Prokopenko, Volodymyr V., Tanchuk, Vsevolod Y., Todeschini, Roberto, Varnek, Alexandre, Marcou, Gilles, Ertl, Peter, Potemkin, Vladimir, Grishina, Maria, Gasteiger, Johann, Schwab, Christof, Baskin, Igor I., Palyulin, Vladimir A., Radchenko, Eugene V., Welsh, William J., Kholodovych, Vladyslav, Chekmarev, Dmitriy, Cherkasov, Artem, Aires-de-Sousa, Joao, Zhang, Qing-You, Bender, Andreas, Nigsch, Florian, Patiny, Luc, Williams, Antony, Tkachenko, Valery, Tetko, Igor V.
Publicado 2011

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

por Cowan, Cameron S., Renner, Magdalena, De Gennaro, Martina, Gross-Scherf, Brigitte, Goldblum, David, Hou, Yanyan, Munz, Martin, Rodrigues, Tiago M., Krol, Jacek, Szikra, Tamas, Cuttat, Rachel, Waldt, Annick, Papasaikas, Panagiotis, Diggelmann, Roland, Patino-Alvarez, Claudia P., Galliker, Patricia, Spirig, Stefan E., Pavlinic, Dinko, Gerber-Hollbach, Nadine, Schuierer, Sven, Srdanovic, Aldin, Balogh, Marton, Panero, Riccardo, Kusnyerik, Akos, Szabo, Arnold, Stadler, Michael B., Orgül, Selim, Picelli, Simone, Hasler, Pascal W., Hierlemann, Andreas, Scholl, Hendrik P.N., Roma, Guglielmo, Nigsch, Florian, Roska, Botond
Publicado 2020