From genome integrity to cancer

por Nik-Zainal, Serena
Publicado 2019

Mutational signatures: experimental design and analytical framework

por Koh, Gene, Zou, Xueqing, Nik-Zainal, Serena
Publicado 2020

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

por Georgakopoulos-Soares, Ilias, Morganella, Sandro, Jain, Naman, Hemberg, Martin, Nik-Zainal, Serena
Publicado 2018

Deciphering Signatures of Mutational Processes Operative in Human Cancer

por Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Campbell, Peter J., Stratton, Michael R.
Publicado 2013

A mutational signature in gastric cancer suggests therapeutic strategies

por Alexandrov, Ludmil B., Nik-Zainal, Serena, Siu, Hoi Cheong, Leung, Suet Yi, Stratton, Michael R
Publicado 2015

Validating the concept of mutational signatures with isogenic cell models

por Zou, Xueqing, Owusu, Michel, Harris, Rebecca, Jackson, Stephen P., Loizou, Joanna I., Nik-Zainal, Serena
Publicado 2018

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

por Georgakopoulos-Soares, Ilias, Koh, Gene, Momen, Sophie E., Jiricny, Josef, Hemberg, Martin, Nik-Zainal, Serena
Publicado 2020

Short inverted repeats contribute to localized mutability in human somatic cells

por Zou, Xueqing, Morganella, Sandro, Glodzik, Dominik, Davies, Helen, Li, Yilin, Stratton, Michael R., Nik-Zainal, Serena
Publicado 2017

APOBEC3A/B deletion polymorphism and cancer risk

por Gansmo, Liv B, Romundstad, Paal, Hveem, Kristian, Vatten, Lars, Nik-Zainal, Serena, Lønning, Per Eystein, Knappskog, Stian
Publicado 2018

Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma

por Jones, Christine L., Degasperi, Andrea, Grandi, Vieri, Amarante, Tauanne D., Mitchell, Tracey J., Nik-Zainal, Serena, Whittaker, Sean J.
Publicado 2021

Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome

por Davies, Helen R., Hodgson, Kirsty, Schwalbe, Edward, Coxhead, Jonathan, Sinclair, Naomi, Zou, Xueqing, Cockell, Simon, Husain, Akhtar, Nik-Zainal, Serena, Rajan, Neil
Publicado 2019

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells

por Rouhani, Foad J., Nik-Zainal, Serena, Wuster, Arthur, Li, Yilong, Conte, Nathalie, Koike-Yusa, Hiroko, Kumasaka, Natsuhiko, Vallier, Ludovic, Yusa, Kosuke, Bradley, Allan
Publicado 2016

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

por Taylor, Benjamin JM, Nik-Zainal, Serena, Wu, Yee Ling, Stebbings, Lucy A, Raine, Keiran, Campbell, Peter J, Rada, Cristina, Stratton, Michael R, Neuberger, Michael S
Publicado 2013

Familial Adrenocortical Carcinoma in Association With Lynch Syndrome

por Challis, Benjamin G., Kandasamy, Narayanan, Powlson, Andrew S., Koulouri, Olympia, Annamalai, Anand Kumar, Happerfield, Lisa, Marker, Alison J., Arends, Mark J., Nik-Zainal, Serena, Gurnell, Mark
Publicado 2016

The genome as a record of environmental exposure

por Nik-Zainal, Serena, Kucab, Jill E., Morganella, Sandro, Glodzik, Dominik, Alexandrov, Ludmil B., Arlt, Volker M., Weninger, Annette, Hollstein, Monica, Stratton, Michael R., Phillips, David H.
Publicado 2015

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

por Inglebert, Marine, Dettwiler, Martina, Hahn, Kerstin, Letko, Anna, Drogemuller, Cord, Doench, John, Brown, Adam, Memari, Yasin, Davies, Helen R., Degasperi, Andrea, Nik-Zainal, Serena, Rottenberg, Sven
Publicado 2022

P442: DDX41 GERMLINE VARIANTS: POPULATION PREVALENCE, SIGNIFICANCE AND LEUKEMIC EVOLUTION

por Cheloor Kovilakam, Sruthi, Gu, Muxin, Dunn, William G., Marando, Ludovica, Barcena, Clea, Nik Zainal, Serena, Mohorianu, Irina, Kar, Siddhartha P., Fabre, Margarete A., Quiros, Pedro M., Vassiliou, George S.
Publicado 2023

Ductal carcinoma in situ: to treat or not to treat, that is the question

por van Seijen, Maartje, Lips, Esther H., Thompson, Alastair M., Nik-Zainal, Serena, Futreal, Andrew, Hwang, E. Shelley, Verschuur, Ellen, Lane, Joanna, Jonkers, Jos, Rea, Daniel W., Wesseling, Jelle
Publicado 2019

Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in...

por Momen, Sophie, Fassihi, Hiva, Davies, Helen R., Nikolaou, Christos, Degasperi, Andrea, Stefanato, Catherine M., Dias, Joao M. L., Dasgupta, Dhruba, Craythorne, Emma, Sarkany, Robert, Papa, Sophie, Nik-Zainal, Serena
Publicado 2019

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells

por Rouhani, Foad J., Zou, Xueqing, Danecek, Petr, Badja, Cherif, Amarante, Tauanne Dias, Koh, Gene, Wu, Qianxin, Memari, Yasin, Durbin, Richard, Martincorena, Inigo, Bassett, Andrew R., Gaffney, Daniel, Nik-Zainal, Serena
Publicado 2022