Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics

por Steffen, Deborah L., Xu, Kai, Nikolov, Dimitar B., Broder, Christopher C.
Publicado 2012

The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation

por Xu, Kai, Olsen, Olav, Tzvetkova-Robev, Dorothea, Tessier-Lavigne, Marc, Nikolov, Dimitar B.
Publicado 2015

Structure of the EphB6 receptor ectodomain

por Mason, Emilia O., Goldgur, Yehuda, Robev, Dorothea, Freywald, Andrew, Nikolov, Dimitar B., Himanen, Juha P.
Publicado 2021

Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study

por Liu, Yixin, Kaljunen, Heidi, Pavić, Ana, Saarenpää, Tuulia, Himanen, Juha P., Nikolov, Dimitar B., Goldman, Adrian
Publicado 2018

The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism

por Xu, Yan, Robev, Dorothea, Saha, Nayanendu, Wang, Bingcheng, Dalva, Matthew B., Xu, Kai, Himanen, Juha P., Nikolov, Dimitar B.
Publicado 2021

New Insights into the Hendra Virus Attachment and Entry Process from Structures of the Virus G Glycoprotein and Its Complex with Ephrin-B2

por Xu, Kai, Chan, Yee-Peng, Rajashankar, Kanagalaghatta R., Khetawat, Dimple, Yan, Lianying, Kolev, Momchil V., Broder, Christopher C., Nikolov, Dimitar B.
Publicado 2012

Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells

por Saha, Nayanendu, Xu, Kai, Zhu, Zhongyu, Robev, Dorothea, Kalidindi, Teja, Xu, Yan, Himanen, Juha, de Stanchina, Elisa, Pillarsetty, Naga Vara Kishore, Dimitrov, Dimiter S, Nikolov, Dimitar B
Publicado 2021

Preferential Antibody and Drug Conjugate Targeting of the ADAM10 Metalloprotease in Tumours

por Yan, Hengkang, Vail, Mary E., Hii, Linda, Guo, Nancy, McMurrick, Paul J., Oliva, Karen, Wilkins, Simon, Saha, Nayanendu, Nikolov, Dimitar B., Lee, Fook-Thean, Scott, Andrew M., Janes, Peter W.
Publicado 2022

Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells

por Saha, Nayanendu, Baek, Du-San, Mendoza, Rachelle P., Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, De La Cruz, M. Jason, de Stanchina, Elisa, Janes, Peter W., Xu, Kai, Dimitrov, Dimiter S., Nikolov, Dimitar B.
Publicado 2023

Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19

por Mendoza, Rachelle, Saha, Nayanendu, Momeni, Amir, Gabutan, Elmer, Alawad, Mouyed, Dehghani, Amir, Diks, John, Lin, Bo, Wang, Donghai, Alshal, Mohamed, Fyke, William, Wang, Bingcheng, Himanen, Juha P., Premsrirut, Prem, Nikolov, Dimitar B.
Publicado 2021

Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus

por Laing, Eric D., Navaratnarajah, Chanakha K., Cheliout Da Silva, Sofia, Petzing, Stephanie R., Xu, Yan, Sterling, Spencer L., Marsh, Glenn A., Wang, Lin-Fa, Amaya, Moushimi, Nikolov, Dimitar B., Cattaneo, Roberto, Broder, Christopher C., Xu, Kai
Publicado 2019

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly

por Xu, Kai, Chan, Yee-Peng, Bradel-Tretheway, Birgit, Akyol-Ataman, Zeynep, Zhu, Yongqun, Dutta, Somnath, Yan, Lianying, Feng, YanRu, Wang, Lin-Fa, Skiniotis, Georgios, Lee, Benhur, Zhou, Z. Hong, Broder, Christopher C., Aguilar, Hector C., Nikolov, Dimitar B.
Publicado 2015

Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody

por Xu, Kai, Rockx, Barry, Xie, Yihu, DeBuysscher, Blair L., Fusco, Deborah L., Zhu, Zhongyu, Chan, Yee-Peng, Xu, Yan, Luu, Truong, Cer, Regina Z., Feldmann, Heinz, Mokashi, Vishwesh, Dimitrov, Dimiter S., Bishop-Lilly, Kimberly A., Broder, Christopher C., Nikolov, Dimitar B.
Publicado 2013

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

por Atapattu, Lakmali, Saha, Nayanendu, Chheang, Chanly, Eissman, Moritz F., Xu, Kai, Vail, Mary E., Hii, Linda, Llerena, Carmen, Liu, Zhanqi, Horvay, Katja, Abud, Helen E., Kusebauch, Ulrike, Moritz, Robert L., Ding, Bi-Sen, Cao, Zhongwei, Rafii, Shahin, Ernst, Matthias, Scott, Andrew M., Nikolov, Dimitar B., Lackmann, Martin, Janes, Peter W.
Publicado 2016

Administration of high titer convalescent anti-SARS-CoV-2 plasma: From donor selection to monitoring recipient outcomes

por Mendoza, Rachelle P., Fyke, William, Daniel, David, Gabutan, Elmer, Das, Ballabh, Bajaj, Harsha, Easy, Maxine, Vasileva, Ana, Colbourn, Robert, Alawad, Mouyed, Dehghani, Amir, Lin, Bo, Emechebe, Dokpe, Patel, Purvi, Jabbar, Absia, Nikolov, Dimitar B., Giovaniello, Dominick, Kang, Steven, Tatem, Luis, Bromberg, Kenneth, Augenbraun, Michael, Premsrirut, Prem, Libien, Jenny, Norin, Allen J.
Publicado 2021

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

por El Zawily, Amr, Vizeacoumar, Frederick S., Dahiya, Renuka, Banerjee, Sara L., Bhanumathy, Kalpana K., Elhasasna, Hussain, Hanover, Glinton, Sharpe, Jessica C., Sanchez, Malkon G., Greidanus, Paul, Stacey, R. Greg, Moon, Kyung-Mee, Alexandrov, Ilya, Himanen, Juha P., Nikolov, Dimitar B., Fonge, Humphrey, White, Aaron P., Foster, Leonard J., Wang, Bingcheng, Toosi, Behzad M., Bisson, Nicolas, Mirzabekov, Tajib A., Vizeacoumar, Franco J., Freywald, Andrew
Publicado 2023