Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

por Lückmann, Michael, Shenol, Aslihan, Nissen, Tinne A. D., Petersen, Jacob E., Kouvchinov, David, Schwartz, Thue W., Frimurer, Thomas M.
Publicado 2022

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

por Lückmann, Michael, Trauelsen, Mette, Bentsen, Marie A., Nissen, Tinne A. D., Martins, Joao, Fallah, Zohreh, Nygaard, Mads M., Papaleo, Elena, Lindorff-Larsen, Kresten, Schwartz, Thue W., Frimurer, Thomas M.
Publicado 2019

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

por Husted, Anna Sofie, Ekberg, Jeppe H., Tripp, Emma, Nissen, Tinne A.D., Meijnikman, Stijn, O'Brien, Shannon L., Ulven, Trond, Acherman, Yair, Bruin, Sjoerd C., Nieuwdorp, Max, Gerhart-Hines, Zach, Calebiro, Davide, Dragsted, Lars O., Schwartz, Thue W.
Publicado 2020