Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

por Hulmi, Juha J., Nissinen, Tuuli A., Penna, Fabio, Bonetto, Andrea
Publicado 2021

Human CD4(+) T Cell Responses to the Dog Major Allergen Can f 1 and Its Human Homologue Tear Lipocalin Resemble Each Other

por Liukko, Aino L. K., Kinnunen, Tuure T., Rytkönen-Nissinen, Marja A., Kailaanmäki, Anssi H. T., Randell, Jukka T., Maillère, Bernard, Virtanen, Tuomas I.
Publicado 2014

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

por Hentilä, Jaakko, Nissinen, Tuuli A., Korkmaz, Ayhan, Lensu, Sanna, Silvennoinen, Mika, Pasternack, Arja, Ritvos, Olli, Atalay, Mustafa, Hulmi, Juha J.
Publicado 2019

Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

por Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivelä, R., Hulmi, J. J.
Publicado 2016

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?

por Pekkala, Satu, Keskitalo, Anniina, Kettunen, Emilia, Lensu, Sanna, Nykänen, Noora, Kuopio, Teijo, Ritvos, Olli, Hentilä, Jaakko, Nissinen, Tuuli A., Hulmi, Juha J.
Publicado 2019

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

por Nissinen, Tuuli A., Hentilä, Jaakko, Penna, Fabio, Lampinen, Anita, Lautaoja, Juulia H., Fachada, Vasco, Holopainen, Tanja, Ritvos, Olli, Kivelä, Riikka, Hulmi, Juha J.
Publicado 2018

Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

por Hulmi, Juha J., Nissinen, Tuuli A., Räsänen, Markus, Degerman, Joni, Lautaoja, Juulia H., Hemanthakumar, Karthik Amudhala, Backman, Janne T., Ritvos, Olli, Silvennoinen, Mika, Kivelä, Riikka
Publicado 2017

Muscle NAD(+) depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins

por Hulmi, J.J., Penna, F., Pöllänen, N., Nissinen, T.A., Hentilä, J., Euro, L., Lautaoja, J.H., Ballarò, R., Soliymani, R., Baumann, M., Ritvos, O., Pirinen, E., Lalowski, M.
Publicado 2020