ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications

por Yi, Ming, Nissley, Dwight V., McCormick, Frank, Stephens, Robert M.
Publicado 2020

Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes

por Shrestha, Rebika, Chen, De, Frank, Peter, Nissley, Dwight V., Turbyville, Thomas J.
Publicado 2021

Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes

por Stephens, Robert M, Yi, Ming, Kessing, Bailey, Nissley, Dwight V, McCormick, Frank
Publicado 2017

Emergency of Primary NNRTI Resistance Mutations without Antiretroviral Selective Pressure in a HAART-Treated Child

por Machado, Elizabeth S., Afonso, Adriana O., Nissley, Dwight V., Lemey, Philippe, Cunha, Silvia M., Oliveira, Ricardo H., Soares, Marcelo A.
Publicado 2009

Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors

por Lai, Lick Pui, Fer, Nicole, Burgan, William, Wall, Vanessa E., Xu, Bingfang, Soppet, Daniel, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank
Publicado 2022

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

por Yan, Wupeng, Markegard, Evan, Dharmaiah, Srisathiyanarayanan, Urisman, Anatoly, Drew, Matthew, Esposito, Dominic, Scheffzek, Klaus, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K.
Publicado 2020

NMR (1)H, (13)C, (15)N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

por Sharma, Alok K., Dyba, Marcin, Tonelli, Marco, Smith, Brian, Gillette, William K., Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Maciag, Anna E.
Publicado 2021

KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner

por Agamasu, Constance, Ghirlando, Rodolfo, Taylor, Troy, Messing, Simon, Tran, Timothy H., Bindu, Lakshman, Tonelli, Marco, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G.
Publicado 2019

The small molecule BI-2852 induces a nonfunctional dimer of KRAS

por Tran, Timothy H., Alexander, Patrick, Dharmaiah, Srisathiyanarayanan, Agamasu, Constance, Nissley, Dwight V., McCormick, Frank, Esposito, Dominic, Simanshu, Dhirendra K., Stephen, Andrew G., Balius, Trent E.
Publicado 2020

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

por Chao, Fa-An, Chan, Albert H., Dharmaiah, Srisathiyanarayanan, Schwieters, Charles D., Tran, Timothy H., Taylor, Troy, Ramakrishnan, Nitya, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K., Cornilescu, Gabriel
Publicado 2023

Membrane curvature sensing of the lipid-anchored K-Ras small GTPase

por Liang, Hong, Mu, Huanwen, Jean-Francois, Frantz, Lakshman, Bindu, Sarkar-Banerjee, Suparna, Zhuang, Yinyin, Zeng, Yongpeng, Gao, Weibo, Zaske, Ana Maria, Nissley, Dwight V, Gorfe, Alemayehu A, Zhao, Wenting, Zhou, Yong
Publicado 2019

Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics

por Ye, Xiaoying, Luke, Brian T., Wei, Bih-Rong, Kaczmarczyk, Jan A., Loncarek, Jadranka, Dwyer, Jennifer E., Johann, Donald J., Saul, Richard G., Nissley, Dwight V., McCormick, Frank, Whiteley, Gordon R., Blonder, Josip
Publicado 2018

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

por Dharmaiah, Srisathiyanarayanan, Tran, Timothy H., Messing, Simon, Agamasu, Constance, Gillette, William K., Yan, Wupeng, Waybright, Timothy, Alexander, Patrick, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Publicado 2019

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

por Desir, Snider, Wong, Phillip, Turbyville, Thomas, Chen, De, Shetty, Mihir, Clark, Christopher, Zhai, Edward, Romin, Yevgeniy, Manova-Todorova, Katia, Starr, Timothy K., Nissley, Dwight V., Steer, Clifford J., Subramanian, Subbaya, Lou, Emil
Publicado 2019

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

por Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
Publicado 2021

AI Meets Exascale Computing: Advancing Cancer Research With Large-Scale High Performance Computing

por Bhattacharya, Tanmoy, Brettin, Thomas, Doroshow, James H., Evrard, Yvonne A., Greenspan, Emily J., Gryshuk, Amy L., Hoang, Thuc T., Lauzon, Carolyn B. Vea, Nissley, Dwight, Penberthy, Lynne, Stahlberg, Eric, Stevens, Rick, Streitz, Fred, Tourassi, Georgia, Xia, Fangfang, Zaki, George
Publicado 2019

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

por Sherekar, Mukul, Han, Sae-Won, Ghirlando, Rodolfo, Messing, Simon, Drew, Matthew, Rabara, Dana, Waybright, Timothy, Juneja, Puneet, O'Neill, Hugh, Stanley, Christopher B., Bhowmik, Debsindhu, Ramanathan, Arvind, Subramaniam, Sriram, Nissley, Dwight V., Gillette, William, McCormick, Frank, Esposito, Dominic
Publicado 2020

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

por Goswami, Debanjan, Chen, De, Yang, Yue, Gudla, Prabhakar R, Columbus, John, Worthy, Karen, Rigby, Megan, Wheeler, Madeline, Mukhopadhyay, Suman, Powell, Katie, Burgan, William, Wall, Vanessa, Esposito, Dominic, Simanshu, Dhirendra K, Lightstone, Felice C, Nissley, Dwight V, McCormick, Frank, Turbyville, Thomas
Publicado 2020

Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization

por Young, Lucy C., Goldstein de Salazar, Ruby, Han, Sae-Won, Huang, Zi Yi Stephanie, Merk, Alan, Drew, Matthew, Darling, Joseph, Wall, Vanessa, Grisshammer, Reinhard, Cheng, Alice, Allison, Madeline R., Sale, Matthew J., Nissley, Dwight V., Esposito, Dominic, Ognjenovic, Jana, McCormick, Frank
Publicado 2023

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

por Gillette, William K., Esposito, Dominic, Abreu Blanco, Maria, Alexander, Patrick, Bindu, Lakshman, Bittner, Cammi, Chertov, Oleg, Frank, Peter H., Grose, Carissa, Jones, Jane E., Meng, Zhaojing, Perkins, Shelley, Van, Que, Ghirlando, Rodolfo, Fivash, Matthew, Nissley, Dwight V., McCormick, Frank, Holderfield, Matthew, Stephen, Andrew G.
Publicado 2015