Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders

por Fisher, Nicole M., Seto, Mabel, Lindsley, Craig W., Niswender, Colleen M.
Publicado 2018

Corrigendum: Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders

por Fisher, Nicole M., Seto, Mabel, Lindsley, Craig W., Niswender, Colleen M.
Publicado 2018

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

por Willis, Brandon S., Niswender, Colleen M., Su, Thomas, Amieux, Paul S., McKnight, G. Stanley
Publicado 2011

T39. NEURAL MECHANISMS OF METABOTROPIC GLUTAMATE RECEPTOR 3 MEDIATED ENHANCEMENT OF SYNAPTIC PLASTICITY AND COGNITION

por Stansley, Branden, Joffe, Max, Yohn, Samantha, Lindsley, Craig, Niswender, Colleen, Jeffrey Conn, P
Publicado 2018

Regulation and functional consequences of mGlu(4) RNA editing

por Hofmann, Christopher S., Carrington, Sheridan, Keller, Andrew N., Gregory, Karen J., Niswender, Colleen M.
Publicado 2021

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

por Senter, Rebecca K., Ghoshal, Ayan, Walker, Adam G., Xiang, Zixiu, Niswender, Colleen M., Conn, P. Jeffrey
Publicado 2016

Optimized Administration of the M(4) PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2(+/–) Mice

por Cikowski, Jakub, Holt, Calista, Arthur, Bright, Smith, Mackenzie, Gonzalez, Sonia, Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.
Publicado 2022

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

por Hammond, Alexis S., Rodriguez, Alice L., Townsend, Steven D., Niswender, Colleen M., Gregory, Karen J., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2010

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling

por Xiang, Zixiu, Lv, Xiaohui, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2019

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

por Vermudez, Sheryl Anne D., Gogliotti, Rocco G., Arthur, Bright, Buch, Aditi, Morales, Clarissa, Moxley, Yuta, Rajpal, Hemangi, Conn, P. Jeffrey, Niswender, Colleen M.
Publicado 2021

Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands

por Presley, Christopher C., Perry, Charles K., Childress, Elizabeth S., Mulder, Matthew J., Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado 2019

Clinical and Preclinical Evidence for M(1) Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

por Smith, Mackenzie, Arthur, Bright, Cikowski, Jakub, Holt, Calista, Gonzalez, Sonia, Fisher, Nicole M., Vermudez, Sheryl Anne D., Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.
Publicado 2022

mGlu(1) potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits

por Maksymetz, James, Byun, Nellie E., Luessen, Deborah J., Li, Brianna, Barry, Robert L., Gore, John C., Niswender, Colleen M., Lindsley, Craig W., Joffe, Max E., Conn, P. Jeffrey
Publicado 2021

Discovery of “Molecular Switches” within a Series of mGlu(5) Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from a...

por Barbaro, Lisa, Rodriguez, Alice L., Blevins, Ashlyn N., Dickerson, Jonathan W., Billard, Natasha, Boutaud, Olivier, Rook, Jerri L., Niswender, Colleen M., Conn, P.Jeffrey, Engers, Darren W., Lindsley, Craig W.
Publicado 2021

Differential activity of mGlu(7) allosteric modulators provides evidence for mGlu(7/8) heterodimers at hippocampal Schaffer collateral-CA1 synapses

por Lin, Xin, Fisher, Nicole M., Dogra, Shalini, Senter, Rebecca K., Reed, Carson W., Kalbfleisch, Jacob J., Lindsley, Craig W., Asher, Wesley B., Xiang, Zixiu, Niswender, Colleen M., Javitch, Jonathan A.
Publicado 2022

Challenges in the Discovery and Optimization of mGlu(2/4) Heterodimer Positive Allosteric Modulators

por Fulton, Mark Gallant, Loch, Matthew Thomas, Cuoco, Caroline Anne, Rodriguez, Alice Lambert, Days, Emily, Vinson, Paige Newton, Kozek, Krystian Andrezej, Weaver, Charles David, Blobaum, Anna Louise, Conn, Peter Jeffrey, Niswender, Colleen Marie, Lindsley, Craig William
Publicado 2019

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

por Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado 2014

Chemical Modulation of Mutant mGlu(1) Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

por Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Brogan, John T., Hopkins, Corey R., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Bubser, Michael, Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado 2014

A GRM7 mutation associated with developmental delay reduces mGlu(7) expression and produces neurological phenotypes

por Fisher, Nicole M., AlHashim, Aqeela, Buch, Aditi B., Badivuku, Hana, Samman, Manar M., Weiss, Kelly M., Cestero, Gabriela I., Does, Mark D., Rook, Jerri M., Lindsley, Craig W., Conn, P. Jeffrey, Gogliotti, Rocco G., Niswender, Colleen M.
Publicado 2021

Discovery of (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Pep...

por Morris, Lindsey C., Nance, Kellie D., Gentry, Patrick R., Days, Emily L., Weaver, C. David, Niswender, Colleen M., Thompson, Analisa D., Jones, Carrie K., Locuson, Chuck W., Morrison, Ryan D., Daniels, J. Scott, Niswender, Kevin D., Lindsley, Craig W.
Publicado 2014