Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies

por Yuan, Aidong, Nixon, Ralph A.
Publicado 2021

Posttranscriptional regulation of neurofilament proteins and tau in health and disease

por Yuan, Aidong, Nixon, Ralph A.
Publicado 2023

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come

por Alam, John J., Nixon, Ralph A.
Publicado 2023

Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come

por Alam, John J., Nixon, Ralph A.
Publicado 2023

The C-Terminal Domains of NF-H and NF-M Subunits Maintain Axonal Neurofilament Content by Blocking Turnover of the Stationary Neurofilament Network

por Rao, Mala V., Yuan, Aidong, Campbell, Jabbar, Kumar, Asok, Nixon, Ralph A.
Publicado 2012

A gene toolbox for monitoring autophagy transcription

por Bordi, Matteo, De Cegli, Rossella, Testa, Beatrice, Nixon, Ralph A., Ballabio, Andrea, Cecconi, Francesco
Publicado 2021

Local Control of Neurofilament Accumulation during Radial Growth of Myelinating Axons in Vivo: Selective Role of Site-Specific Phosphorylation

por Sánchez, Ivelisse, Hassinger, Linda, Sihag, Ram K., Cleveland, Don W., Mohan, Panaiyur, Nixon, Ralph A.
Publicado 2000

The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neur...

por Rao, Mala V., Campbell, Jabbar, Yuan, Aidong, Kumar, Asok, Gotow, Takahiro, Uchiyama, Yasuo, Nixon, Ralph A.
Publicado 2003

Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

por Annunziata, Ida, Patterson, Annette, Helton, Danielle, Hu, Huimin, Moshiach, Simon, Gomero, Elida, Nixon, Ralph, d’Azzo, Alessandra
Publicado 2013

Dissociation of Axonal Neurofilament Content from Its Transport Rate

por Yuan, Aidong, Hassinger, Linda, Rao, Mala V., Julien, Jean-Pierre, Miller, Christopher C. J., Nixon, Ralph A.
Publicado 2015

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

por Bordi, Matteo, Darji, Sandipkumar, Sato, Yutaka, Mellén, Marian, Berg, Martin J., Kumar, Asok, Jiang, Ying, Nixon, Ralph A.
Publicado 2019

Spared Piriform Cortical Single-Unit Odor Processing and Odor Discrimination in the Tg2576 Mouse Model of Alzheimer's Disease

por Xu, Wenjin, Lopez-Guzman, Mirielle, Schoen, Chelsea, Fitzgerald, Shane, Lauer, Stephanie L., Nixon, Ralph A., Levy, Efrat, Wilson, Donald A.
Publicado 2014

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

por Xue, Xue, Wang, Li-Rong, Sato, Yutaka, Jiang, Ying, Berg, Martin, Yang, Dun-Sheng, Nixon, Ralph A., Liang, Xing-Jie
Publicado 2014

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

por Bordi, Matteo, Berg, Martin J., Mohan, Panaiyur S., Peterhoff, Corrinne M., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Nixon, Ralph A.
Publicado 2016

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function

por Lie, Pearl P. Y., Yoo, Lang, Goulbourne, Chris N., Berg, Martin J., Stavrides, Philip, Huo, Chunfeng, Lee, Ju-Hyun, Nixon, Ralph A.
Publicado 2022

The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum (ER) Content and Distribution within Axons

por Rao, Mala V., Mohan, Panaiyur S., Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M., Julien, Jean P., Nixon, Ralph A.
Publicado 2011

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP βCTF

por Im, Eunju, Jiang, Ying, Stavrides, Philip H., Darji, Sandipkumar, Erdjument-Bromage, Hediye, Neubert, Thomas A., Choi, Jun Yong, Wegiel, Jerzy, Lee, Ju-Hyun, Nixon, Ralph A.
Publicado 2023

Autophagy is a novel pathway for neurofilament protein degradation in vivo

por Rao, Mala V., Darji, Sandipkumar, Stavrides, Philip H., Goulbourne, Chris N., Kumar, Asok, Yang, Dun-Sheng, Yoo, Lang, Peddy, James, Lee, Ju-Hyun, Yuan, Aidong, Nixon, Ralph A.
Publicado 2022

Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transpo...

por Rao, Mala V., Garcia, Michael L., Miyazaki, Yukio, Gotow, Takahiro, Yuan, Aidong, Mattina, Salvatore, Ward, Chris M., Calcutt, Nigel A., Uchiyama, Yasuo, Nixon, Ralph A., Cleveland, Don W.
Publicado 2002

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

por Tizon, Belen, Sahoo, Susmita, Yu, Haung, Gauthier, Sebastien, Kumar, Asok R., Mohan, Panaiyur, Figliola, Matthew, Pawlik, Monika, Grubb, Anders, Uchiyama, Yasuo, Bandyopadhyay, Urmi, Cuervo, Ana Maria, Nixon, Ralph A., Levy, Efrat
Publicado 2010