TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas

por Nobrega, Marcelo A.
Publicado 2013

Identifying synonymous regulatory elements in vertebrate genomes

por Ovcharenko, Ivan, Nobrega, Marcelo A.
Publicado 2005

Transcriptional enhancers in development and disease

por Sakabe, Noboru Jo, Savic, Daniel, Nobrega, Marcelo A
Publicado 2012

An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers

por Savic, Daniel, Bell, Graeme I., Nobrega, Marcelo A.
Publicado 2012

Modulation of Tcf7l2 Expression Alters Behavior in Mice

por Savic, Daniel, Distler, Margaret G., Sokoloff, Greta, Shanahan, Nancy A., Dulawa, Stephanie C., Palmer, Abraham A., Nobrega, Marcelo A.
Publicado 2011

Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice

por Bailey, Kathleen A., Savic, Daniel, Zielinski, Mark, Park, Soo-Young, Wang, Ling-jia, Witkowski, Piotr, Brady, Matthew, Hara, Manami, Bell, Graeme I., Nobrega, Marcelo A.
Publicado 2015

A promoter interaction map for cardiovascular disease genetics

por Montefiori, Lindsey E, Sobreira, Debora R, Sakabe, Noboru J, Aneas, Ivy, Joslin, Amelia C, Hansen, Grace T, Bozek, Grazyna, Moskowitz, Ivan P, McNally, Elizabeth M, Nóbrega, Marcelo A
Publicado 2018

A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans

por Gray, Olivia A., Yoo, Jennifer, Sobreira, Débora R., Jousma, Jordan, Witonsky, David, Sakabe, Noboru J., Peng, Ying-Jie, Prabhakar, Nanduri R., Fang, Yun, Nobréga, Marcelo A., Di Rienzo, Anna
Publicado 2022

FTO-Mediated Formation of N(6)-Hydroxymethyladenosine and N(6)-Formyladenosine in Mammalian RNA

por Fu, Ye, Jia, Guifang, Pang, Xueqin, Wang, Richard N., Wang, Xiao, Li, Charles J., Smemo, Scott, Dai, Qing, Bailey, Kathleen A., Nobrega, Marcelo A., Han, Ke-li, Cui, Qiang, He, Chuan
Publicado 2013

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

por Boogerd, Cornelis J., Zhu, Xiaoming, Aneas, Ivy, Sakabe, Noboru, Zhang, Lunfeng, Sobreira, Debora R., Montefiori, Lindsey, Bogomolovas, Julius, Joslin, Amelia C., Zhou, Bin, Chen, Ju, Nobrega, Marcelo A., Evans, Sylvia M.
Publicado 2018

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

por Joslin, Amelia C., Sobreira, Débora R., Hansen, Grace T., Sakabe, Noboru J., Aneas, Ivy, Montefiori, Lindsey E., Farris, Kathryn M., Gu, Jing, Lehman, Donna M., Ober, Carole, He, Xin, Nóbrega, Marcelo A.
Publicado 2021

Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma

por Helling, Britney A., Sobreira, Débora R., Hansen, Grace T., Sakabe, Noboru J., Luo, Kaixuan, Billstrand, Christine, Laxman, Bharathi, Nicolae, Raluca I., Nicolae, Dan L., Bochkov, Yury A., Gern, James E., Nobrega, Marcelo A., White, Steven R., Ober, Carole
Publicado 2020

Regulation of MEIS1 by Distal Enhancer Elements in Acute Leukemia

por Wang, Qian-fei, Li, Ya-jun, Dong, Jing-fang, Li, Bo, Kaberlein, Joseph J., Zhang, Lin, Arimura, Fábio Eiji, Luo, Roger T., Ni, Jun, He, Fuhong, Wu, Jun, Mattison, Ryan, Zhou, Jing, Wang, Chong-zhi, Prabhakar, Shyam, Nobrega, Marcelo A., Thirman, Michael J.
Publicado 2013

Single cell profiling at the maternal–fetal interface reveals a deficiency of PD-L1(+) non-immune cells in human spontaneous preterm labor

por Liu, Xiao, Aneas, Ivy, Sakabe, Noboru, Anderson, Rebecca L., Billstrand, Christine, Paz, Cristina, Kaur, Harjot, Furner, Brian, Choi, Seong, Prichina, Adriana Y., Enninga, Elizabeth Ann L., Dong, Haidong, Murtha, Amy, Crawford, Gregory E., Kessler, John A., Grobman, William, Nobrega, Marcelo A., Rana, Sarosh, Ober, Carole
Publicado 2023

Advancing human health in the decade ahead: pregnancy as a key window for discovery: A Burroughs Wellcome Fund Pregnancy Think Tank

por Sadovsky, Yoel, Mesiano, Sam, Burton, Graham J., Lampl, Michelle, Murray, Jeffrey C., Freathy, Rachel M., Mahadevan-Jansen, Anita, Moffett, Ashley, Price, Nathan D., Wise, Paul H., Wildman, Derek E., Snyderman, Ralph, Paneth, Nigel, Capra, John Anthony, Nobrega, Marcelo A., Barak, Yaacov, Muglia, Louis J.
Publicado 2020

Identification of atrial fibrillation associated genes and functional non-coding variants

por van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M.
Publicado 2019

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

por Sakabe, Noboru J., Aneas, Ivy, Knoblauch, Nicholas, Sobreira, Debora R., Clark, Nicole, Paz, Cristina, Horth, Cynthia, Ziffra, Ryan, Kaur, Harjot, Liu, Xiao, Anderson, Rebecca, Morrison, Jean, Cheung, Virginia C., Grotegut, Chad, Reddy, Timothy E., Jacobsson, Bo, Hallman, Mikko, Teramo, Kari, Murtha, Amy, Kessler, John, Grobman, William, Zhang, Ge, Muglia, Louis J., Rana, Sarosh, Lynch, Vincent J., Crawford, Gregory E., Ober, Carole, He, Xin, Nóbrega, Marcelo A.
Publicado 2020

Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region

por Aneas, Ivy, Decker, Donna C., Howard, Chanie L., Sobreira, Débora R., Sakabe, Noboru J., Blaine, Kelly M., Stein, Michelle M., Hrusch, Cara L., Montefiori, Lindsey E., Tena, Juan, Magnaye, Kevin M., Clay, Selene M., Gern, James E., Jackson, Daniel J., Altman, Matthew C., Naureckas, Edward T., Hogarth, Douglas K., White, Steven R., Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I., Nóbrega, Marcelo A.
Publicado 2021

Obesity-associated variants within FTO form long-range functional connections with IRX3

por Smemo, Scott, Tena, Juan J., Kim, Kyoung-Han, Gamazon, Eric R., Sakabe, Noboru J., Gómez-Marín, Carlos, Aneas, Ivy, Credidio, Flavia L., Sobreira, Débora R., Wasserman, Nora F., Lee, Ju Hee, Puviindran, Vijitha, Tam, Davis, Shen, Michael, Son, Joe Eun, Vakili, Niki Alizadeh, Sung, Hoon-Ki, Naranjo, Silvia, Acemel, Rafael D., Manzanares, Miguel, Nagy, Andras, Cox, Nancy J., Hui, Chi-Chung, Gomez-Skarmeta, Jose Luis, Nóbrega, Marcelo A.
Publicado 2014

African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

por Washington, Charles, Dapas, Matthew, Biddanda, Arjun, Magnaye, Kevin M., Aneas, Ivy, Helling, Britney A., Szczesny, Brooke, Boorgula, Meher Preethi, Taub, Margaret A., Kenny, Eimear, Mathias, Rasika A., Barnes, Kathleen C., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gereige, Jessica D., Makhija, Melanie, Gruchalla, Rebecca S., Gill, Michelle A., Liu, Andrew H., Rastogi, Deepa, Busse, William, Gergen, Peter J., Visness, Cynthia M., Gold, Diane R., Hartert, Tina, Johnson, Christine C., Lemanske, Robert F., Martinez, Fernando D., Miller, Rachel L., Ownby, Dennis, Seroogy, Christine M., Wright, Anne L., Zoratti, Edward M., Bacharier, Leonard B., Kattan, Meyer, O’Connor, George T., Wood, Robert A., Nobrega, Marcelo A., Altman, Matthew C., Jackson, Daniel J., Gern, James E., McKennan, Christopher G., Ober, Carole
Publicado 2022