Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes

por Sin, Olga, Nollen, Ellen A. A.
Publicado 2015

Regulation of Age-Related Protein Toxicity

por Pras, Anita, Nollen, Ellen A. A.
Publicado 2021

Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors and decreases fecundity

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Publicado 2023

Cellular Regulation of Amyloid Formation in Aging and Disease

por Stroo, Esther, Koopman, Mandy, Nollen, Ellen A. A., Mata-Cabana, Alejandro
Publicado 2017

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies

por Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Hogewerf, Wytse, Nollen, Ellen A. A.
Publicado 2023

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms

por van Ham, Tjakko J, Breitling, Rainer, Swertz, Morris A, Nollen, Ellen A A
Publicado 2009

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

por Sorgdrager, Freek J. H., Naudé, Petrus J. W., Kema, Ido P., Nollen, Ellen A., Deyn, Peter P. De
Publicado 2019

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation

por Teuling, Eva, Bourgonje, Annika, Veenje, Sven, Thijssen, Karen, de Boer, Jelle, van der Velde, Joeri, Swertz, Morris, Nollen, Ellen
Publicado 2011

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

por van Ham, Tjakko J., Thijssen, Karen L., Breitling, Rainer, Hofstra, Robert M. W., Plasterk, Ronald H. A., Nollen, Ellen A. A.
Publicado 2008

Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

por Sorgdrager, Freek J. H., Vermeiren, Yannick, Van Faassen, Martijn, van der Ley, Claude, Nollen, Ellen A. A., Kema, Ido P., De Deyn, Peter P.
Publicado 2019

Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration

por Siudeja, Katarzyna, Srinivasan, Balaji, Xu, Lanjun, Rana, Anil, de Jong, Jannie, Nollen, Ellen A A, Jackowski, Suzanne, Sanford, Lynn, Hayflick, Susan, Sibon, Ody C M
Publicado 2011

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

por Janssens, Georges E., Lin, Xin-Xuan, Millan-Ariño, Lluís, Kavšek, Alan, Sen, Ilke, Seinstra, Renée I., Stroustrup, Nicholas, Nollen, Ellen A.A., Riedel, Christian G.
Publicado 2019

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

por Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.
Publicado 2016

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

por Habchi, Johnny, Arosio, Paolo, Perni, Michele, Costa, Ana Rita, Yagi-Utsumi, Maho, Joshi, Priyanka, Chia, Sean, Cohen, Samuel I. A., Müller, Martin B. D., Linse, Sara, Nollen, Ellen A. A., Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Publicado 2016

SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly

por Falsone, S. Fabio, Meyer, N. Helge, Schrank, Evelyne, Leitinger, Gerd, Pham, Chi L.L., Fodero-Tavoletti, Michelle T., Holmberg, Mats, Dulle, Martin, Scicluna, Benjamin, Gesslbauer, Bernd, Rückert, Hanna-Marie, Wagner, Gabriel E., Merle, David A., Nollen, Ellen A., Kungl, Andreas J., Hill, Andrew F., Cappai, Roberto, Zangger, Klaus
Publicado 2012

The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation

por Pras, Anita, Houben, Bert, Aprile, Francesco A, Seinstra, Renée, Gallardo, Rodrigo, Janssen, Leen, Hogewerf, Wytse, Gallrein, Christian, De Vleeschouwer, Matthias, Mata‐Cabana, Alejandro, Koopman, Mandy, Stroo, Esther, de Vries, Minke, Louise Edwards, Samantha, Kirstein, Janine, Vendruscolo, Michele, Falsone, Salvatore Fabio, Rousseau, Frederic, Schymkowitz, Joost, Nollen, Ellen A A
Publicado 2021

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

por Sin, Olga, de Jong, Tristan, Mata-Cabana, Alejandro, Kudron, Michelle, Zaini, Mohamad Amr, Aprile, Francesco A., Seinstra, Renée I., Stroo, Esther, Prins, Roméo Willinge, Martineau, Céline N., Wang, Hai Hui, Hogewerf, Wytse, Steinhof, Anne, Wanker, Erich E., Vendruscolo, Michele, Calkhoven, Cornelis F., Reinke, Valerie, Guryev, Victor, Nollen, Ellen A.A.
Publicado 2017

Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

por Stroo, Esther, Janssen, Leen, Sin, Olga, Hogewerf, Wytse, Koster, Mirjam, Harkema, Liesbeth, Youssef, Sameh A, Beschorner, Natalie, Wolters, Anouk HG, Bakker, Bjorn, Becker, Lore, Garrett, Lilian, Marschall, Susan, Hoelter, Sabine M, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Thathiah, Amantha, Foijer, Floris, van de Sluis, Bart, van Deursen, Jan, Jucker, Matthias, de Bruin, Alain, Nollen, Ellen AA
Publicado 2023