Early Onset Parkinson’s Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report

por Norman, Brendan P., Lubbe, Steven J., Tan, Manuela, Warren, Naomi, Morris, Huw R.
Publicado 2017

Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria

por Davison, Andrew S., Norman, Brendan P., Sutherland, Hazel, Milan, Anna M., Gallagher, James A., Jarvis, Jonathan C., Ranganath, Lakshminarayan R.
Publicado 2022

Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial

por Ooi, Nicola, Cooper, Ian R., Norman, Brendan, Gallagher, James A., Sireau, Nick, Bou-Gharios, George, Ranganath, Lakshminarayan R., Savage, Victoria J.
Publicado 2023

Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS

por Davison, Andrew S., Norman, Brendan P., Ross, Gordon A., Hughes, Andrew T., Khedr, Milad, Milan, Anna M., Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2019

The Regulatory Role of MicroRNAs in Breast Cancer

por Loh, Hui-Yi, Norman, Brendan P., Lai, Kok-Song, Rahman, Nik Mohd Afizan Nik Abd., Alitheen, Noorjahan Banu Mohamed, Osman, Mohd Azuraidi
Publicado 2019

Increased prevalence of Parkinson's disease in alkaptonuria

por Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.
Publicado 2023

Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

por Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut
Publicado 2020

Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review

por Loh, Hui-Yi, Norman, Brendan P., Lai, Kok-Song, Cheng, Wan-Hee, Nik Abd. Rahman, Nik Mohd Afizan, Mohamed Alitheen, Noorjahan Banu, Osman, Mohd Azuraidi
Publicado 2023

Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard
Publicado 2021

Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen...

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A.
Publicado 2022

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

por Ranganath, Lakshminarayan R., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A., Milan, Anna M.
Publicado 2022

Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the ge...

por Hughes, Juliette H, Liu, Ke, Plagge, Antonius, Wilson, Peter J M, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao, Ranganath, Lakshminarayan R, Gallagher, James A, Bou-Gharios, George
Publicado 2019

Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

por Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM., Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.
Publicado 2021

Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

por Norman, Brendan P., Davison, Andrew S., Hickton, Bryony, Ross, Gordon A., Milan, Anna M., Hughes, Andrew T., Wilson, Peter J. M., Sutherland, Hazel, Hughes, Juliette H., Roberts, Norman B., Bou-Gharios, George, Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2022