Rehabilitating drug-induced long-QT promoters: In-silico design of hERG-neutral cisapride analogues with retained pharmacological activity

por Durdagi, Serdar, Randall, Trevor, Duff, Henry J, Chamberlin, Adam, Noskov, Sergei Y
Publicado 2014

K(+) Block Is the Mechanism of Functional Asymmetry in Bacterial Na(v) Channels

por Ngo, Van, Wang, Yibo, Haas, Stephan, Noskov, Sergei Y., Farley, Robert A.
Publicado 2016

Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

por Concilio, Susanna C., Zhekova, Hristina R., Noskov, Sergei Y., Russell, Stephen J.
Publicado 2020

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations

por DeMarco, Kevin R., Bekker, Slava, Clancy, Colleen E., Noskov, Sergei Y., Vorobyov, Igor
Publicado 2018

Ion selectivity in channels and transporters

por Roux, Benoît, Bernèche, Simon, Egwolf, Bernhard, Lev, Bogdan, Noskov, Sergei Y., Rowley, Christopher N., Yu, Haibo
Publicado 2011

Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy

por Finol-Urdaneta, Rocio K., Wang, Yibo, Al-Sabi, Ahmed, Zhao, Chunfeng, Noskov, Sergei Y., French, Robert J.
Publicado 2014

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

por Guo, Jiqing, Durdagi, Serdar, Changalov, Mohamed, Perissinotti, Laura L., Hargreaves, Jason M., Back, Thomas G., Noskov, Sergei Y., Duff, Henry J.
Publicado 2014

Magic Angle Spinning Nuclear Magnetic Resonance Characterization of Voltage-Dependent Anion Channel Gating in Two-Dimensional Lipid Crystalline Bilayers

por Eddy, Matthew T., Andreas, Loren, Teijido, Oscar, Su, Yongchao, Clark, Lindsay, Noskov, Sergei Y., Wagner, Gerhard, Rostovtseva, Tatiana K., Griffin, Robert G.
Publicado 2014

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study

por Perissinotti, Laura L., De Biase, Pablo M., Guo, Jiqing, Yang, Pei-Chi, Lee, Miranda C., Clancy, Colleen E., Duff, Henry J., Noskov, Sergei Y.
Publicado 2018

A molecular switch controls the impact of cholesterol on a Kir channel

por Corradi, Valentina, Bukiya, Anna N., Miranda, Williams E., Cui, Meng, Plant, Leigh D., Logothetis, Diomedes E., Tieleman, D. Peter, Noskov, Sergei Y., Rosenhouse-Dantsker, Avia
Publicado 2022

In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia

por Yang, Pei‐Chi, Moreno, Jonathan D., Miyake, Christina Y., Vaughn‐Behrens, Steven B., Jeng, Mao‐Tsuen, Grandi, Eleonora, Wehrens, Xander H. T., Noskov, Sergei Y., Clancy, Colleen E.
Publicado 2016

A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal‐induced arrhythmias

por Yang, Pei‐Chi, Perissinotti, Laura L., López‐Redondo, Fernando, Wang, Yibo, DeMarco, Kevin R., Jeng, Mao‐Tsuen, Vorobyov, Igor, Harvey, Robert D., Kurokawa, Junko, Noskov, Sergei Y., Clancy, Colleen E.
Publicado 2017

Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline

por DeMarco, Kevin R., Yang, Pei-Chi, Singh, Vikrant, Furutani, Kazuharu, Dawson, John R. D., Jeng, Mao-Tsuen, Fettinger, James C., Bekker, Slava, Ngo, Van A., Noskov, Sergei Y., Yarov-Yarovoy, Vladimir, Sack, Jon T., Wulff, Heike, Clancy, Colleen E., Vorobyov, Igor
Publicado 2021