One-step construction of circularized nanodiscs using SpyCatcher-SpyTag

por Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan
Publicado 2021

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

por Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.
Publicado 2021

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

por Patil, Dipak N, Rangarajan, Erumbi S, Novick, Scott J, Pascal, Bruce D, Kojetin, Douglas J, Griffin, Patrick R, Izard, Tina, Martemyanov, Kirill A
Publicado 2018

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988

por Frkic, Rebecca L., Chua, Benjamin S., Shin, Youseung, Pascal, Bruce D., Novick, Scott J., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

por Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Publicado 2019

Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

por Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Publicado 2019

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

por Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.
Publicado 2019

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

por Zheng, Jie, Wang, Chen, Chang, Mi Ra, Devarkar, Swapnil C., Schweibenz, Brandon, Crynen, Gogce C., Garcia-Ordonez, Ruben D., Pascal, Bruce D., Novick, Scott J., Patel, Smita S., Marcotrigiano, Joseph, Griffin, Patrick R.
Publicado 2018

Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia

por Cyr, Matthew G, Mhibik, Maissa, Qi, Junpeng, Peng, Haiyong, Chang, Jing, Gaglione, Erika M, Eik, David, Herrick, John, Venables, Thomas, Novick, Scott J, Courouble, Valentine V, Griffin, Patrick R, Wiestner, Adrian, Rader, Christoph
Publicado 2022

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

por Sun, Litao, Wei, Na, Kuhle, Bernhard, Blocquel, David, Novick, Scott, Matuszek, Zaneta, Zhou, Huihao, He, Weiwei, Zhang, Jingjing, Weber, Thomas, Horvath, Rita, Latour, Philippe, Pan, Tao, Schimmel, Paul, Griffin, Patrick R., Yang, Xiang-Lei
Publicado 2021

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

por Zheng, Jie, Chang, Mi Ra, Stites, Ryan E., Wang, Yong, Bruning, John B., Pascal, Bruce D., Novick, Scott J., Garcia-Ordonez, Ruben D., Stayrook, Keith R., Chalmers, Michael J., Dodge, Jeffrey A., Griffin, Patrick R.
Publicado 2017

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

por Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Publicado 2017

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

por Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L
Publicado 2016

Pharmacological Repression of PPARγ Promotes Osteogenesis

por Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Douglas J., Phinney, Donald G., Bruning, John B., Kamenecka, Theodore M., Griffin, Patrick R.
Publicado 2015

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

por Srinivasan, Sathish, Nwachukwu, Jerome C., Bruno, Nelson E., Dharmarajan, Venkatasubramanian, Goswami, Devrishi, Kastrati, Irida, Novick, Scott, Nowak, Jason, Cavett, Valerie, Zhou, Hai-Bing, Boonmuen, Nittaya, Zhao, Yuechao, Min, Jian, Frasor, Jonna, Katzenellenbogen, Benita S., Griffin, Patrick R., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2016