A generic protocol for protein crystal dehydration using the HC1b humidity controller

por Lobley, Carina M. C., Sandy, James, Sanchez-Weatherby, Juan, Mazzorana, Marco, Krojer, Tobias, Nowak, Radosław P., Sorensen, Thomas L.
Publicado 2016

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

por Gasic, Ivana, Groendyke, Brian J., Nowak, Radosław P., Yuan, J. Christine, Kalabathula, Joann, Fischer, Eric S., Gray, Nathanael S., Mitchison, Timothy J.
Publicado 2020

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

por Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
Publicado 2018

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

por Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
Publicado 2019

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

por Tarhonskaya, Hanna, Nowak, Radosław P., Johansson, Catrine, Szykowska, Aleksandra, Tumber, Anthony, Hancock, Rebecca L., Lang, Pauline, Flashman, Emily, Oppermann, Udo, Schofield, Christopher J., Kawamura, Akane
Publicado 2017

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

por Hanzl, Alexander, Barone, Eleonora, Bauer, Sophie, Yue, Hong, Nowak, Radosław P., Hahn, Elisa, Pankevich, Eugenia V., Koren, Anna, Kubicek, Stefan, Fischer, Eric S., Winter, Georg E.
Publicado 2023

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

por Silva, M. Catarina, Nandi, Ghata, Donovan, Katherine A., Cai, Quan, Berry, Bethany C., Nowak, Radoslaw P., Fischer, Eric S., Gray, Nathanael S., Ferguson, Fleur M., Haggarty, Stephen J.
Publicado 2022

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

por Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Publicado 2017

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

por Thinnes, Cyrille C., Lohans, Christopher T., Abboud, Martine I., Yeh, Tzu‐Lan, Tumber, Anthony, Nowak, Radosław P., Attwood, Martin, Cockman, Matthew E., Oppermann, Udo, Loenarz, Christoph, Schofield, Christopher J.
Publicado 2019

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

por de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.
Publicado 2019

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell‐Free Expression Systems

por Dubey, Abhinav, Stoyanov, Nikolay, Viennet, Thibault, Chhabra, Sandeep, Elter, Shantha, Borggräfe, Jan, Viegas, Aldino, Nowak, Radosław P., Burdzhiev, Nikola, Petrov, Ognyan, Fischer, Eric S., Etzkorn, Manuel, Gelev, Vladimir, Arthanari, Haribabu
Publicado 2021

Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead

por Nowak, Radosław P., Ragosta, Leah, Huerta, Fidel, Liu, Hu, Ficarro, Scott B., Cruite, Justin T., Metivier, Rebecca J., Donovan, Katherine A., Marto, Jarrod A., Fischer, Eric S., Zerfas, Breanna L., Jones, Lyn H.
Publicado 2023

Acute pharmacological degradation of Helios destabilizes regulatory T cells

por Wang, Eric S., Verano, Alyssa L., Nowak, Radosław P., Yuan, J. Christine, Donovan, Katherine A., Eleuteri, Nicholas A., Yue, Hong, Ngo, Kenneth H., Lizotte, Patrick H., Gokhale, Prafulla C., Gray, Nathanael S., Fischer, Eric S.
Publicado 2021

Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center

por Meyerhardt, Jeffrey A., Yue, Hong, Nowak, Radosław P., Brais, Lauren, Ma, Chao, Johnson, Samantha, Harrod, Joanna, Burman, Shourya S. Roy, Hendrickson, Lynn M., Fischinger, Stephanie, Alter, Galit, Hahn, William, Johnson, Bruce E., Fischer, Eric S.
Publicado 2022

Plasticity in binding confers selectivity in ligand induced protein degradation

por Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.
Publicado 2018

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes

por Cruite, Justin T., Dann, Geoffrey P., Che, Jianwei, Donovan, Katherine A., Ferrao, Silas, Ficarro, Scott B., Fischer, Eric S., Gray, Nathanael S., Huerta, Fidel, Kong, Nikki R., Liu, Hu, Marto, Jarrod A., Metivier, Rebecca J., Nowak, Radosław P., Zerfas, Breanna L., Jones, Lyn H.
Publicado 2022

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

por Zou, Charles, Yoon, Hojong, Park, Paul M.C., Patten, J.J., Pellman, Jesse, Carreiro, Jeannie, Tsai, Jonathan M., Li, Yen-Der, Roy Burman, Shourya S., Donovan, Katherine A., Gasser, Jessica, Sperling, Adam S., Nowak, Radosław P., Fischer, Eric S., Davey, Robert A., Ebert, Benjamin L., Słabicki, Mikołaj
Publicado 2023

Small molecule-induced polymerization triggers degradation of BCL6

por Słabicki, Mikołaj, Yoon, Hojong, Koeppel, Jonas, Nitsch, Lena, Roy Burman, Shourya S., Di Genua, Cristina, Donovan, Katherine A., Sperling, Adam S., Hunkeler, Moritz, Tsai, Jonathan M., Sharma, Rohan, Guirguis, Andrew, Zou, Charles, Chudasama, Priya, Gasser, Jessica A., Miller, Peter G., Scholl, Claudia, Fröhling, Stefan, Nowak, Radosław P., Fischer, Eric S., Ebert, Benjamin L.
Publicado 2020

Attenuated response to SARS-CoV-2 vaccine in patients with asymptomatic precursor stages of multiple myeloma and Waldenstrom macroglobulinemia

por Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Yue, Hong, Ferrari, Federico, Redd, Robert A., Lightbody, Elizabeth D., Russo, Massimiliano, Perry, Jacqueline, Horowitz, Erica, Justis, Anna V., Shayegh, Nader A., Savell, Alexandra, Prescott, Julia, Varmeh, Shohreh, Nowak, Radosław P., Hamilton, Mark, Auclair, Daniel, Marinac, Catherine R., Trippa, Lorenzo, Fischer, Eric S., Ghobrial, Irene M.
Publicado 2022

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

por Nowak, Radosław P., Tumber, Anthony, Hendrix, Eline, Ansari, Mohammad Salik Zeya, Sabatino, Manuela, Antonini, Lorenzo, Andrijes, Regina, Salah, Eidarus, Mautone, Nicola, Pellegrini, Francesca Romana, Simelis, Klemensas, Kawamura, Akane, Johansson, Catrine, Passeri, Daniela, Pellicciari, Roberto, Ciogli, Alessia, Del Bufalo, Donatella, Ragno, Rino, Coleman, Mathew L., Trisciuoglio, Daniela, Mai, Antonello, Oppermann, Udo, Schofield, Christopher J., Rotili, Dante
Publicado 2021