The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies

por Errico, Francesco, Nuzzo, Tommaso, Carella, Massimo, Bertolino, Alessandro, Usiello, Alessandro
Publicado 2018

New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications

por Usiello, Alessandro, Di Fiore, Maria Maddalena, De Rosa, Arianna, Falvo, Sara, Errico, Francesco, Santillo, Alessandra, Nuzzo, Tommaso, Chieffi Baccari, Gabriella
Publicado 2020

Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients

por De Rosa, Arianna, Di Maio, Anna, Torretta, Silvia, Garofalo, Martina, Giorgelli, Valentina, Masellis, Rita, Nuzzo, Tommaso, Errico, Francesco, Bertolino, Alessandro, Subramaniam, Srinivasa, Rampino, Antonio, Usiello, Alessandro
Publicado 2022

Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain

por De Rosa, Arianna, Fontana, Andrea, Nuzzo, Tommaso, Garofalo, Martina, Di Maio, Anna, Punzo, Daniela, Copetti, Massimiliano, Bertolino, Alessandro, Errico, Francesco, Rampino, Antonio, de Bartolomeis, Andrea, Usiello, Alessandro
Publicado 2022

Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients

por Nuzzo, Tommaso, Sacchi, Silvia, Errico, Francesco, Keller, Simona, Palumbo, Orazio, Florio, Ermanno, Punzo, Daniela, Napolitano, Francesco, Copetti, Massimiliano, Carella, Massimo, Chiariotti, Lorenzo, Bertolino, Alessandro, Pollegioni, Loredano, Usiello, Alessandro
Publicado 2017

Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients

por Nuzzo, Tommaso, Russo, Rosita, Errico, Francesco, D’Amico, Adele, Tewelde, Awet G., Valletta, Mariangela, Hassan, Amber, Tosi, Michele, Panicucci, Chiara, Bruno, Claudio, Bertini, Enrico, Chambery, Angela, Pellizzoni, Livio, Usiello, Alessandro
Publicado 2023

Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients

por Di Maio, Anna, De Rosa, Arianna, Pelucchi, Silvia, Garofalo, Martina, Marciano, Benedetta, Nuzzo, Tommaso, Gardoni, Fabrizio, Isidori, Andrea M., Di Luca, Monica, Errico, Francesco, De Bartolomeis, Andrea, Marcello, Elena, Usiello, Alessandro
Publicado 2022

Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum

por Cuomo, Mariella, Keller, Simona, Punzo, Daniela, Nuzzo, Tommaso, Affinito, Ornella, Coretti, Lorena, Carella, Massimo, de Rosa, Valeria, Florio, Ermanno, Boscia, Francesca, Avvedimento, Vittorio Enrico, Cocozza, Sergio, Errico, Francesco, Usiello, Alessandro, Chiariotti, Lorenzo
Publicado 2019

SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

por Valsecchi, Valeria, Errico, Francesco, Bassareo, Valentina, Marino, Carmen, Nuzzo, Tommaso, Brancaccio, Paola, Laudati, Giusy, Casamassa, Antonella, Grimaldi, Manuela, D’Amico, Adele, Carta, Manolo, Bertini, Enrico, Pignataro, Giuseppe, D’Ursi, Anna Maria, Usiello, Alessandro
Publicado 2023

Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity

por Sacchi, Silvia, Novellis, Vito De, Paolone, Giovanna, Nuzzo, Tommaso, Iannotta, Monica, Belardo, Carmela, Squillace, Marta, Bolognesi, Paolo, Rosini, Elena, Motta, Zoraide, Frassineti, Martina, Bertolino, Alessandro, Pollegioni, Loredano, Morari, Michele, Maione, Sabatino, Errico, Francesco, Usiello, Alessandro
Publicado 2017

Nusinersen Induces Disease-Severity-Specific Neurometabolic Effects in Spinal Muscular Atrophy

por Errico, Francesco, Marino, Carmen, Grimaldi, Manuela, Nuzzo, Tommaso, Bassareo, Valentina, Valsecchi, Valeria, Panicucci, Chiara, Di Schiavi, Elia, Mazza, Tommaso, Bruno, Claudio, D’Amico, Adele, Carta, Manolo, D’Ursi, Anna Maria, Bertini, Enrico, Pellizzoni, Livio, Usiello, Alessandro
Publicado 2022

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

por Nuzzo, Tommaso, Punzo, Daniela, Devoto, Paola, Rosini, Elena, Paciotti, Silvia, Sacchi, Silvia, Li, Qin, Thiolat, Marie-Laure, Véga, Celine, Carella, Massimo, Carta, Manolo, Gardoni, Fabrizio, Calabresi, Paolo, Pollegioni, Loredano, Bezard, Erwan, Parnetti, Lucilla, Errico, Francesco, Usiello, Alessandro
Publicado 2019

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease

por Eshraghi, Mehdi, Ramírez-Jarquín, Uri Nimrod, Shahani, Neelam, Nuzzo, Tommaso, De Rosa, Arianna, Swarnkar, Supriya, Galli, Nicole, Rivera, Oscar, Tsaprailis, George, Scharager-Tapia, Catherina, Crynen, Gogce, Li, Qin, Thiolat, Marie-Laure, Bezard, Erwan, Usiello, Alessandro, Subramaniam, Srinivasa
Publicado 2020

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses

por Napolitano, Francesco, De Rosa, Arianna, Russo, Rosita, Di Maio, Anna, Garofalo, Martina, Federici, Mauro, Migliarini, Sara, Ledonne, Ada, Rizzo, Francesca Romana, Avallone, Luigi, Nuzzo, Tommaso, Biagini, Tommaso, Pasqualetti, Massimo, Mercuri, Nicola Biagio, Mazza, Tommaso, Chambery, Angela, Usiello, Alessandro
Publicado 2019

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

por Lombardo, Barbara, Pagani, Marco, De Rosa, Arianna, Nunziato, Marcella, Migliarini, Sara, Garofalo, Martina, Terrile, Marta, D’Argenio, Valeria, Galbusera, Alberto, Nuzzo, Tommaso, Ranieri, Annaluisa, Vitale, Andrea, Leggiero, Eleonora, Di Maio, Anna, Barsotti, Noemi, Borello, Ugo, Napolitano, Francesco, Mandarino, Alessandra, Carotenuto, Marco, Heresco-Levy, Uriel, Pasqualetti, Massimo, Malatesta, Paolo, Gozzi, Alessandro, Errico, Francesco, Salvatore, Francesco, Pastore, Lucio, Usiello, Alessandro
Publicado 2022