OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence

por De Rosa, Mariarosaria, Barnes, Ryan P., Nyalapatla, Prasanth R., Wipf, Peter, Opresko, Patricia L.
Publicado 2023

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

por St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., Mesecar, Andrew D.
Publicado 2015

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

por Tomar, Sakshi, Johnston, Melanie L., St. John, Sarah E., Osswald, Heather L., Nyalapatla, Prasanth R., Paul, Lake N., Ghosh, Arun K., Denison, Mark R., Mesecar, Andrew D.
Publicado 2015

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

por Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado 2020

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

por Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Publicado 2017