T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

por Daniel, Sara, Nylander, Vibe, Ingerslev, Lars R., Zhong, Ling, Fabre, Odile, Clifford, Briana, Johnston, Karen, Cohn, Richard J., Barres, Romain, Simar, David
Publicado 2018

A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes

por Torres, Jason M., Abdalla, Moustafa, Payne, Anthony, Fernandez-Tajes, Juan, Thurner, Matthias, Nylander, Vibe, Gloyn, Anna L., Mahajan, Anubha, McCarthy, Mark I.
Publicado 2020

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells

por Torres, Jason M., Sun, Han, Nylander, Vibe, Downes, Damien J., van de Bunt, Martijn, McCarthy, Mark I., Hughes, Jim R., Gloyn, Anna L.
Publicado 2023

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

por Wesolowska-Andersen, Agata, Zhuo Yu, Grace, Nylander, Vibe, Abaitua, Fernando, Thurner, Matthias, Torres, Jason M, Mahajan, Anubha, Gloyn, Anna L, McCarthy, Mark I
Publicado 2020

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

por Hastoy, Benoît, Godazgar, Mahdieh, Clark, Anne, Nylander, Vibe, Spiliotis, Ioannis, van de Bunt, Martijn, Chibalina, Margarita V., Barrett, Amy, Burrows, Carla, Tarasov, Andrei I., Scharfmann, Raphael, Gloyn, Anna L., Rorsman, Patrik
Publicado 2018

Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation

por Wesolowska-Andersen, Agata, Jensen, Rikke Rejnholdt, Alcántara, Marta Pérez, Beer, Nicola L., Duff, Claire, Nylander, Vibe, Gosden, Matthew, Witty, Lorna, Bowden, Rory, McCarthy, Mark I., Hansson, Mattias, Gloyn, Anna L., Honore, Christian
Publicado 2019

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

por Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I
Publicado 2018

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

por Alonso, Lorena, Piron, Anthony, Morán, Ignasi, Guindo-Martínez, Marta, Bonàs-Guarch, Sílvia, Atla, Goutham, Miguel-Escalada, Irene, Royo, Romina, Puiggròs, Montserrat, Garcia-Hurtado, Xavier, Suleiman, Mara, Marselli, Lorella, Esguerra, Jonathan L.S., Turatsinze, Jean-Valéry, Torres, Jason M., Nylander, Vibe, Chen, Ji, Eliasson, Lena, Defrance, Matthieu, Amela, Ramon, Mulder, Hindrik, Gloyn, Anna L., Groop, Leif, Marchetti, Piero, Eizirik, Decio L., Ferrer, Jorge, Mercader, Josep M., Cnop, Miriam, Torrents, David
Publicado 2021

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

por Viñuela, Ana, Varshney, Arushi, van de Bunt, Martijn, Prasad, Rashmi B., Asplund, Olof, Bennett, Amanda, Boehnke, Michael, Brown, Andrew A., Erdos, Michael R., Fadista, João, Hansson, Ola, Hatem, Gad, Howald, Cédric, Iyengar, Apoorva K., Johnson, Paul, Krus, Ulrika, MacDonald, Patrick E., Mahajan, Anubha, Manning Fox, Jocelyn E., Narisu, Narisu, Nylander, Vibe, Orchard, Peter, Oskolkov, Nikolay, Panousis, Nikolaos I., Payne, Anthony, Stitzel, Michael L., Vadlamudi, Swarooparani, Welch, Ryan, Collins, Francis S., Mohlke, Karen L., Gloyn, Anna L., Scott, Laura J., Dermitzakis, Emmanouil T., Groop, Leif, Parker, Stephen C. J., McCarthy, Mark I.
Publicado 2020