Quantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments

por O’Brien, Edward J., Utrilla, Jose, Palsson, Bernhard O.
Publicado 2016

Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli

por Seo, Sang Woo, Kim, Donghyuk, O'Brien, Edward J., Szubin, Richard, Palsson, Bernhard O.
Publicado 2015

Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction

por O’Brien, Edward J, Lerman, Joshua A, Chang, Roger L, Hyduke, Daniel R, Palsson, Bernhard Ø
Publicado 2013

Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli

por Seo, Sang Woo, Kim, Donghyuk, Latif, Haythem, O’Brien, Edward J., Szubin, Richard, Palsson, Bernhard O.
Publicado 2014

130. Design and Preclinical Characterization of SER-155, an Investigational Cultivated Microbiome Therapeutic to Restore Colonization Resistance and Prevent Infection in Patients U...

por Halvorsen, Elizabeth, Vulic, Marin, O’Brien, Edward J, Byrant, Jessica, Lombardo, Mary-Jane, Ford, Christopher, Henn, Matt
Publicado 2021

Reconstruction and modeling protein translocation and compartmentalization in Escherichia coli at the genome-scale

por Liu, Joanne K, O’Brien, Edward J, Lerman, Joshua A, Zengler, Karsten, Palsson, Bernhard O, Feist, Adam M
Publicado 2014

COBRAme: A computational framework for genome-scale models of metabolism and gene expression

por Lloyd, Colton J., Ebrahim, Ali, Yang, Laurence, King, Zachary A., Catoiu, Edward, O’Brien, Edward J., Liu, Joanne K., Palsson, Bernhard O.
Publicado 2018

2156. The Rational Design of SER-147: a Cultivated Microbial Consortium to Restore Colonization Resistance and Mitigate Infection in Chronic Liver Disease

por Wurster, Jenna, Straub, Tim, O’Brien, Edward J, Ennis, Nathaniel J, Mayol, Melissa, Brown, Jessica, Vulić, Marin, Beauchemin, Nicholas, Halvorsen, Elizabeth, Ford, Christopher, Henn, Matthew
Publicado 2023

2067. Preclinical Characterization of Rationally Designed Microbial Consortia to Prevent Bacterial Infections in Patients with Chronic Liver Disease

por Halvorsen, Elizabeth, Vulić, Marin, Barrasso, Kelsey, Beauchemin, Nicholas, Brown, Jessica, Ennis, Nathaniel J, Mayol, Melissa, Wurster, Jenna, O’Brien, Edward J, Ford, Christopher, Henn, Matthew
Publicado 2023

Systems biology of the structural proteome

por Brunk, Elizabeth, Mih, Nathan, Monk, Jonathan, Zhang, Zhen, O’Brien, Edward J., Bliven, Spencer E., Chen, Ke, Chang, Roger L., Bourne, Philip E., Palsson, Bernhard O.
Publicado 2016

Multi-omic data integration enables discovery of hidden biological regularities

por Ebrahim, Ali, Brunk, Elizabeth, Tan, Justin, O'Brien, Edward J., Kim, Donghyuk, Szubin, Richard, Lerman, Joshua A., Lechner, Anna, Sastry, Anand, Bordbar, Aarash, Feist, Adam M., Palsson, Bernhard O.
Publicado 2016

Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism

por Cheng, Chuankai, O’Brien, Edward J., McCloskey, Douglas, Utrilla, Jose, Olson, Connor, LaCroix, Ryan A., Sandberg, Troy E., Feist, Adam M., Palsson, Bernhard O., King, Zachary A.
Publicado 2019

The genetic basis for adaptation of model-designed syntrophic co-cultures

por Lloyd, Colton J., King, Zachary A., Sandberg, Troy E., Hefner, Ying, Olson, Connor A., Phaneuf, Patrick V., O’Brien, Edward J., Sanders, Jon G., Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory, Knight, Rob, Feist, Adam M.
Publicado 2019

A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis

por Henn, Matthew R., O’Brien, Edward J., Diao, Liyang, Feagan, Brian G., Sandborn, William J., Huttenhower, Curtis, Wortman, Jennifer R., McGovern, Barbara H., Wang-Weigand, Sherry, Lichter, David I., Chafee, Meghan, Ford, Christopher B., Bernardo, Patricia, Zhao, Peng, Simmons, Sheri, Tomlinson, Amelia D., Cook, David N., Pomerantz, Roger J., Misra, Bharat K., Auninš, John G., Trucksis, Michele
Publicado 2021

SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial

por McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R, Pardi, Darrell S, Khanna, Sahil, Hohmann, Elizabeth L, O’Brien, Edward J, Desjardins, Christopher A, Bernardo, Patricia, Wortman, Jennifer R, Lombardo, Mary-Jane, Litcofsky, Kevin D, Winkler, Jonathan A, McChalicher, Christopher W J, Li, Sunny S, Tomlinson, Amelia D, Nandakumar, Madhumitha, Cook, David N, Pomerantz, Roger J, Auninš, John G, Trucksis, Michele
Publicado 2020