N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels

por Alexander, Veronica J, Xia, Shuting, Hurh, Eunju, Hughes, Steven G, O’Dea, Louis, Geary, Richard S, Witztum, Joseph L, Tsimikas, Sotirios
Publicado 2019

Treatment with Volanesorsen, a 2′-O-Methoxyethyl-Modified Antisense Oligonucleotide Targeting APOC3 mRNA, Does Not Affect the QTc Interval in Healthy Volunteers

por Watts, Lynnetta M., Karwatowska-Prokopczuk, Ewa, Hurh, Eunju, Alexander, Veronica J., Balogh, Kristin, O'Dea, Louis, Geary, Richard S., Tsimikas, Sotirios
Publicado 2020

Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and...

por Gaudet, Daniel, Karwatowska-Prokopczuk, Ewa, Baum, Seth J, Hurh, Eunju, Kingsbury, Joyce, Bartlett, Victoria J, Figueroa, Amparo L, Piscitelli, Philip, Singleton, Walter, Witztum, Joseph L, Geary, Richard S, Tsimikas, Sotirios, O'Dea, Louis St. L
Publicado 2020

Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles

por O’Dea, Louis St L, MacDougall, James, Alexander, Veronica J, Digenio, Andres, Hubbard, Brant, Arca, Marcello, Moriarty, Patrick M, Kastelein, John J P, Bruckert, Eric, Soran, Handrean, Witztum, Joseph L, Hegele, Robert A, Gaudet, Daniel
Publicado 2019

Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk

por Tardif, Jean-Claude, Karwatowska-Prokopczuk, Ewa, Amour, Eric St, Ballantyne, Christie M, Shapiro, Michael D, Moriarty, Patrick M, Baum, Seth J, Hurh, Eunju, Bartlett, Victoria J, Kingsbury, Joyce, Figueroa, Amparo L, Alexander, Veronica J, Tami, Joseph, Witztum, Joseph L, Geary, Richard S, O’Dea, Louis St L, Tsimikas, Sotirios, Gaudet, Daniel
Publicado 2022

Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-L(Rx) (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneu...

por Coelho, Teresa, Ando, Yukio, Benson, Merrill D., Berk, John L., Waddington-Cruz, Márcia, Dyck, Peter J., Gillmore, Julian D., Khella, Sami L., Litchy, William J., Obici, Laura, Monteiro, Cecilia, Tai, Li-Jung, Viney, Nicholas J., Buchele, Gustavo, Brambatti, Michela, Jung, Shiangtung W., St. L. O’Dea, Louis, Tsimikas, Sotirios, Schneider, Eugene, Geary, Richard S., Monia, Brett P., Gertz, Morie
Publicado 2021