Template‐Directed Copying of RNA by Non‐enzymatic Ligation

por Zhou, Lijun, O'Flaherty, Derek K., Szostak, Jack W.
Publicado 2020

Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells

por O’Flaherty, Derek K., Zhou, Lijun, Szostak, Jack W.
Publicado 2019

Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation

por Zhou, Lijun, O’Flaherty, Derek K., Szostak, Jack W.
Publicado 2020

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

por Kim, Seohyun Chris, O’Flaherty, Derek K., Zhou, Lijun, Lelyveld, Victor S., Szostak, Jack W.
Publicado 2018

A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension

por Giurgiu, Constantin, Li, Li, O’Flaherty, Derek K., Tam, Chun Pong, Szostak, Jack W.
Publicado 2017

DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates

por Lelyveld, Victor S, O’Flaherty, Derek K, Zhou, Lijun, Izgu, Enver Cagri, Szostak, Jack W
Publicado 2019

Copying of Mixed-Sequence RNA Templates inside Model Protocells

por O’Flaherty, Derek K., Kamat, Neha P., Mirza, Fatima N., Li, Li, Prywes, Noam, Szostak, Jack W.
Publicado 2018

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

por Kim, Seohyun Chris, Zhou, Lijun, Zhang, Wen, O’Flaherty, Derek K., Rondo-Brovetto, Valeria, Szostak, Jack W.
Publicado 2020

Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage

por Wright, Tom H., Giurgiu, Constantin, Zhang, Wen, Radakovic, Aleksandar, O’Flaherty, Derek K., Zhou, Lijun, Szostak, Jack W.
Publicado 2019

Non-enzymatic primer extension with strand displacement

por Zhou, Lijun, Kim, Seohyun Chris, Ho, Katherine H, O'Flaherty, Derek K, Giurgiu, Constantin, Wright, Tom H, Szostak, Jack W
Publicado 2019

Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells

por Rubio-Sánchez, Roger, O’Flaherty, Derek K., Wang, Anna, Coscia, Francesca, Petris, Gianluca, Di Michele, Lorenzo, Cicuta, Pietro, Bonfio, Claudia
Publicado 2021

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides

por Li, Li, Prywes, Noam, Tam, Chun Pong, O’Flaherty, Derek K., Lelyveld, Victor S., Izgu, Enver Cagri, Pal, Ayan, Szostak, Jack W.
Publicado 2017

Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein

por Schoonhoven, Nadia M., O’Flaherty, Derek K., McManus, Francis P., Sacre, Lauralicia, Noronha, Anne M., Kornblatt, M. Judith, Wilds, Christopher J.
Publicado 2017

Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides

por Janicki, Mikołaj J., Kufner, Corinna L., Todd, Zoe R., Kim, Seohyun C., O’Flaherty, Derek K., Szostak, Jack W., Šponer, Jiří, Góra, Robert W., Sasselov, Dimitar D., Szabla, Rafał
Publicado 2021

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′...

por Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O’Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah
Publicado 2021