Targeting cellular senescence with novel senotherapeutics by design to extend healthspan

por Zhang, Lei, Hughes, Brian, Angelini, Luise, O’Kelly, Ryan, Yousefzadeh, Matthew, Kamenecka, Ted, Niedernhofer, Laura, Robbins, Paul
Publicado 2021

Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model

por Grange, Cristina, Papadimitriou, Elli, Dimuccio, Veronica, Pastorino, Cecilia, Molina, Jordi, O’Kelly, Ryan, Niedernhofer, Laura J., Robbins, Paul D., Camussi, Giovanni, Bussolati, Benedetta
Publicado 2020

Acute Biventricular Mechanical Circulatory Support for Cardiogenic Shock

por Kuchibhotla, Sudeep, Esposito, Michele L., Breton, Catalina, Pedicini, Robert, Mullin, Andrew, O'Kelly, Ryan, Anderson, Mark, Morris, Dennis L., Batsides, George, Ramzy, Danny, Grise, Mark, Pham, Duc Thinh, Kapur, Navin K.
Publicado 2017

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

por Zhang, Lei, Zhao, Jing, Mu, Xiaodong, McGowan, Sara J., Angelini, Luise, O'Kelly, Ryan D., Yousefzadeh, Matthew J., Sakamoto, Ayumi, Aversa, Zaira, LeBrasseur, Nathan K., Suh, Yousin, Huard, Johnny, Kamenecka, Theodore M., Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2021

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

por Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U., McGowan, Sara J., Angelini, Luise, O’Kelly, Ryan, Li, Hongshuai, Corbo, Lana, Sano, Tokio, Nick, Heather, Pola, Enrico, Pilla, Smitha P.S., Ladiges, Warren C., Vo, Nam, Huard, Johnny, Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2020

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy

por Henpita, Chathurika, Vyas, Rajesh, Healy, Chastity L., Kieu, Tra L., Gurkar, Aditi U., Yousefzadeh, Matthew J., Cui, Yuxiang, Lu, Aiping, Angelini, Luise A., O'Kelly, Ryan D., McGowan, Sara J., Chandrasekhar, Sanjay, Vanderpool, Rebecca R., Hennessy‐Wack, Danielle, Ross, Mark A., Bachman, Timothy N., McTiernan, Charles, Pillai, Smitha P. S., Ladiges, Warren, Lavasani, Mitra, Huard, Johnny, Beer‐Stolz, Donna, St. Croix, Claudette M., Watkins, Simon C., Robbins, Paul D., Mora, Ana L., Kelley, Eric E., Wang, Yinsheng, O'Connell, Timothy D., Niedernhofer, Laura J.
Publicado 2023

Senolytics reduce coronavirus-related mortality in old mice

por Camell, Christina D., Yousefzadeh, Matthew J., Zhu, Yi, Prata, Larissa G. P. Langhi, Huggins, Matthew A., Pierson, Mark, Zhang, Lei, O’Kelly, Ryan D., Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J., Inman, Christina L., Johnson, Kurt O., Cholensky, Stephanie H., Carlson, Timothy W., LeBrasseur, Nathan K., Khosla, Sundeep, O’Sullivan, M. Gerard, Allison, David B., Jameson, Stephen C., Meves, Alexander, Li, Ming, Prakash, Y. S., Chiarella, Sergio E., Hamilton, Sara E., Tchkonia, Tamara, Niedernhofer, Laura J., Kirkland, James L., Robbins, Paul D.
Publicado 2021