Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects

por Berg, Ellen L., Polokoff, Mark A., O’Mahony, Alison, Nguyen, Dat, Li, Xitong
Publicado 2015

Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate

por O’Mahony, Alison, John, Markus R., Cho, Hannah, Hashizume, Misato, Choy, Ernest H.
Publicado 2018

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures

por Singer, Jack W., Al-Fayoumi, Suliman, Taylor, Jason, Velichko, Sharlene, O’Mahony, Alison
Publicado 2019

Regulation of IL-17A Production Is Distinct from IL-17F in a Primary Human Cell Co-culture Model of T Cell-Mediated B Cell Activation

por Melton, Andrew C., Melrose, Jennifer, Alajoki, Liisa, Privat, Sylvie, Cho, Hannah, Brown, Naomi, Plavec, Ana Marija, Nguyen, Dat, Johnston, Elijah D., Yang, Jian, Polokoff, Mark A., Plavec, Ivan, Berg, Ellen L., O'Mahony, Alison
Publicado 2013

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

por Ciceri, Pietro, Müller, Susanne, O’Mahony, Alison, Fedorov, Oleg, Filippakopoulos, Panagis, Hunt, Jeremy P., Lasater, Elisabeth A., Pallares, Gabriel, Picaud, Sarah, Wells, Christopher, Martin, Sarah, Wodicka, Lisa M., Shah, Neil P., Treiber, Daniel K., Knapp, Stefan
Publicado 2014

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

por Jackson, Thomas R., Vuorinen, Aini, Josa-Culleré, Laia, Madden, Katrina S., Conole, Daniel, Cogswell, Thomas J., Wilkinson, Isabel V.L., Kettyle, Laura M., Zhang, Douzi, O’Mahony, Alison, Gracias, Deanne, McCall, Lorna, Westwood, Robert, Terstappen, Georg C., Davies, Stephen G., Tate, Edward W., Wynne, Graham M., Vyas, Paresh, Russell, Angela J., Milne, Thomas A.
Publicado 2022